ENSMUSG00000021108


Mus musculus

Features
Gene ID: ENSMUSG00000021108
  
Biological name :Prkch
  
Synonyms : P23298 / Prkch / protein kinase C, eta
  
Possible biological names infered from orthology : P24723
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 73584796
Gene end: 73778185
  
Corresponding Affymetrix probe sets: 10396402 (MoGene1.0st)   10396419 (MoGene1.0st)   1422079_at (Mouse Genome 430 2.0 Array)   1434248_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021527
Ensembl peptide - ENSMUSP00000152346
NCBI entrez gene - 18755     See in Manteia.
MGI - MGI:97600
RefSeq - NM_001313977
RefSeq - NM_008856
RefSeq Peptide - NP_001300906
RefSeq Peptide - NP_032882
swissprot - P23298
swissprot - A0A1Y7VJ89
Ensembl - ENSMUSG00000021108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkchaENSDARG00000018382Danio rerio
 prkchbENSDARG00000043243Danio rerio
 PRKCHENSGALG00000011889Gallus gallus
 PRKCHENSG00000027075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503864
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194842
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677841
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288941
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881640
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096540
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764333
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905332
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172927
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997026
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405626
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969926
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591525
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027431  Protein kinase C, eta
 IPR034665  Novel protein kinase C eta, catalytic domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0070528 protein kinase C signaling IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0004699 calcium-independent protein kinase C activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj8sos/Kcnj8sos
Genetic Background: C57BL/6J-Kcnj8sos

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Kcnj8sos/Kcnj8sos
Genetic Background: C57BL/6J-Kcnj8sos

 MP:0003671 abnormal eyelid opening 
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0005231 abnormal brachial lymph node morphology "anomalous structure, development, or number of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0009631 enlarged axillary lymph nodes "increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Fig4tm1.1Mm/Fig4tm1.1Mm,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tbx4tm1.1Pa/Tbx4tm1.1Pa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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