ENSMUSG00000078816


Mus musculus

Features
Gene ID: ENSMUSG00000078816
  
Biological name :Prkcg
  
Synonyms : P63318 / Prkcg / protein kinase C, gamma
  
Possible biological names infered from orthology : P05129
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 3289179
Gene end: 3331099
  
Corresponding Affymetrix probe sets: 10608705 (MoGene1.0st)   1421446_at (Mouse Genome 430 2.0 Array)   1455758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097874
Ensembl peptide - ENSMUSP00000131351
Ensembl peptide - ENSMUSP00000145498
NCBI entrez gene - 18752     See in Manteia.
MGI - MGI:97597
RefSeq - NM_001291434
RefSeq - NM_011102
RefSeq Peptide - NP_001278363
RefSeq Peptide - NP_035232
swissprot - Q3UN66
swissprot - P63318
swissprot - Q2NKI4
swissprot - A0A0N4SWF4
Ensembl - ENSMUSG00000078816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcgENSDARG00000004561Danio rerio
 PRKCGENSG00000126583Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288969
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096569
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503841
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677839
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110839
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194839
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905329
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764329
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172925
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969925
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405625
Sgk1 / Q9WVC6 / Serine/threonine-protein kinase Sgk1 / O00141* / serum/glucocorticoid regulated kinase 1*ENSMUSG0000001997024
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591523
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786820


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007635 chemosensory behavior IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0032095 regulation of response to food IMP
 biological_processGO:0032425 positive regulation of mismatch repair IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:1901799 negative regulation of proteasomal protein catabolic process IMP
 biological_processGO:1990911 response to psychosocial stress IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0097060 synaptic membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0004698 calcium-dependent protein kinase C activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0001987 alcohol preference 
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syngap1tm1.1Mabk/Syngap1tm1.2Mabk,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cckbrtm1Tom/Cckbr+
Genetic Background: B6.129S4-Cckbrtm1Tom

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

Allelic Composition: Prkcgtm1Stl/Prkcgtm1Stl
Genetic Background: B6.129-Prkcgtm1Stl

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk7tm1Jdl/Mapk7tm1Jdl,Tg(Myhca-cre)1Abel/0
Genetic Background: Not Specified

Allelic Composition: Prkcgtm1Stl/Prkcgtm1Stl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkcgtm1Stl/Prkcgtm1Stl
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027882 Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*  / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction






 

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