ENSMUSG00000027882


Mus musculus

Features
Gene ID: ENSMUSG00000027882
  
Biological name :Stxbp3
  
Synonyms : Q60770 / Stxbp3 / Syntaxin-binding protein 3
  
Possible biological names infered from orthology : O00186
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F3
Gene start: 108793176
Gene end: 108840526
  
Corresponding Affymetrix probe sets: 10465853 (MoGene1.0st)   10501420 (MoGene1.0st)   1416653_at (Mouse Genome 430 2.0 Array)   1435058_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099681
Ensembl peptide - ENSMUSP00000142860
Ensembl peptide - ENSMUSP00000142785
Ensembl peptide - ENSMUSP00000102206
NCBI entrez gene - 20912     See in Manteia.
MGI - MGI:107362
RefSeq - NM_011504
RefSeq Peptide - NP_035634
swissprot - A0A0G2JEQ3
swissprot - A0A0G2JEI5
swissprot - A2AEC9
swissprot - Q60770
Ensembl - ENSMUSG00000027882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stxbp3ENSDARG00000008142Danio rerio
 STXBP3ENSGALG00000002001Gallus gallus
 O00186ENSG00000116266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O08599 / Stxbp1 / Syntaxin-binding protein 1 / P61764*ENSMUSG0000002679739
Q64324 / Stxbp2 / syntaxin binding protein 2 / Q15833*ENSMUSG0000000462635


Protein motifs (from Interpro)
Interpro ID Name
 IPR001619  Sec1-like protein
 IPR036045  Sec1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0022615 protein to membrane docking IMP
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0043312 neutrophil degranulation IEA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0070820 tertiary granule IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Notch3tm1Ul/Notch3+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / complex
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction
 ENSMUSG00000052889 Prkcb / P68404 / protein kinase C, beta / P05771*  / reaction
 ENSMUSG00000078816 Prkcg / P63318 / protein kinase C, gamma / P05129*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr