ENSMUSG00000026797


Mus musculus

Features
Gene ID: ENSMUSG00000026797
  
Biological name :Stxbp1
  
Synonyms : O08599 / Stxbp1 / Syntaxin-binding protein 1
  
Possible biological names infered from orthology : P61764
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32787602
Gene end: 32847245
  
Corresponding Affymetrix probe sets: 10481711 (MoGene1.0st)   1420505_a_at (Mouse Genome 430 2.0 Array)   1420506_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146437
Ensembl peptide - ENSMUSP00000052440
Ensembl peptide - ENSMUSP00000089051
NCBI entrez gene - 20910     See in Manteia.
MGI - MGI:107363
RefSeq - NM_001113569
RefSeq - NM_009295
RefSeq Peptide - NP_001107041
RefSeq Peptide - NP_033321
swissprot - A0A140LHJ4
swissprot - O08599
Ensembl - ENSMUSG00000026797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stxbp1aENSDARG00000001994Danio rerio
 stxbp1bENSDARG00000056036Danio rerio
 STXBP1ENSGALG00000040003Gallus gallus
 P61764ENSG00000136854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q64324 / Stxbp2 / syntaxin binding protein 2 / Q15833*ENSMUSG0000000462661
Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*ENSMUSG0000002788239


Protein motifs (from Interpro)
Interpro ID Name
 IPR001619  Sec1-like protein
 IPR036045  Sec1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation IEA
 biological_processGO:0003006 developmental process involved in reproduction IEA
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007412 axon target recognition IMP
 biological_processGO:0010807 regulation of synaptic vesicle priming IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016188 synaptic vesicle maturation IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0031338 regulation of vesicle fusion IEA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane TAS
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0099525 presynaptic dense core vesicle exocytosis IMP
 biological_processGO:0106022 positive regulation of vesicle docking IEA
 biological_processGO:1903296 positive regulation of glutamate secretion, neurotransmission IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031091 platelet alpha granule IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IDA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098891 extrinsic component of presynaptic active zone membrane IC
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IDA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043274 phospholipase binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cpefat/Cpefat
Genetic Background: BKSChpLt.HRS-Cpefat/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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