ENSMUSG00000004626


Mus musculus

Features
Gene ID: ENSMUSG00000004626
  
Biological name :Stxbp2
  
Synonyms : Q64324 / Stxbp2 / syntaxin binding protein 2
  
Possible biological names infered from orthology : Q15833
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 3630955
Gene end: 3643644
  
Corresponding Affymetrix probe sets: 10569848 (MoGene1.0st)   1416449_x_at (Mouse Genome 430 2.0 Array)   1437048_x_at (Mouse Genome 430 2.0 Array)   1448341_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146468
Ensembl peptide - ENSMUSP00000125405
Ensembl peptide - ENSMUSP00000146798
Ensembl peptide - ENSMUSP00000147220
Ensembl peptide - ENSMUSP00000147088
Ensembl peptide - ENSMUSP00000004745
NCBI entrez gene - 20911     See in Manteia.
MGI - MGI:107370
RefSeq - XM_017312633
RefSeq - NM_011503
RefSeq - XM_006508742
RefSeq - XM_006508743
RefSeq - XM_006508746
RefSeq - XM_011242046
RefSeq - XM_017312632
RefSeq Peptide - NP_035633
swissprot - Q64324
swissprot - A0A140LJH9
swissprot - A0A140LJ60
swissprot - Q548T0
swissprot - A0A140LIF1
swissprot - A0A140LHM1
swissprot - F8WGM5
Ensembl - ENSMUSG00000004626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stxbp2ENSDARG00000007603Danio rerio
 Q15833ENSG00000076944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O08599 / Stxbp1 / Syntaxin-binding protein 1 / P61764*ENSMUSG0000002679762
Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*ENSMUSG0000002788235


Protein motifs (from Interpro)
Interpro ID Name
 IPR001619  Sec1-like protein
 IPR036045  Sec1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001909 leukocyte mediated cytotoxicity IEA
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0006904 vesicle docking involved in exocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0043312 neutrophil degranulation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0042582 azurophil granule IEA
 cellular_componentGO:0042589 zymogen granule membrane IDA
 cellular_componentGO:0044194 cytolytic granule IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0070820 tertiary granule IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IPI
 molecular_functionGO:0019905 syntaxin binding TAS
 molecular_functionGO:0030348 syntaxin-3 binding ISO


Pathways (from Reactome)
Pathway description
Platelet degranulation
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Satb1m1Anu/Satb1+
Genetic Background: C57L/6JAnu-Satb1m1Anu

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Npr2pwe/Npr2pwe
Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007207 Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*  / complex






 

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