ENSMUSG00000007207


Mus musculus

Features
Gene ID: ENSMUSG00000007207
  
Biological name :Stx1a
  
Synonyms : O35526 / Stx1a / syntaxin 1A (brain)
  
Possible biological names infered from orthology : Q16623 / syntaxin 1A
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 135023482
Gene end: 135051100
  
Corresponding Affymetrix probe sets: 10526261 (MoGene1.0st)   1437390_x_at (Mouse Genome 430 2.0 Array)   1448366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117144
Ensembl peptide - ENSMUSP00000144082
Ensembl peptide - ENSMUSP00000005509
NCBI entrez gene - 20907     See in Manteia.
MGI - MGI:109355
RefSeq - NM_016801
RefSeq - XM_006504400
RefSeq Peptide - NP_058081
swissprot - D6RFB9
swissprot - O35526
swissprot - Q497P1
swissprot - A0A0J9YUA0
Ensembl - ENSMUSG00000007207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx1aENSDARG00000058994Danio rerio
 STX1AENSGALG00000041722Gallus gallus
 STX1AENSG00000106089Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stx1b / P61264 / Syntaxin-1B / P61266*ENSMUSG0000003080684
Stx2 / syntaxin 2 / P32856*ENSMUSG0000002942863
Stx3 / Q64704 / Syntaxin-3 / Q13277*ENSMUSG0000004148863
Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*ENSMUSG0000003080545
Stx11 / syntaxin 11 / O75558*ENSMUSG0000003923231
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*ENSMUSG0000004785428
Gm379ENSMUSG0000009391626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR028669  Syntaxin 1A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IGI
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010701 positive regulation of norepinephrine secretion IEA
 biological_processGO:0010807 regulation of synaptic vesicle priming IGI
 biological_processGO:0016081 synaptic vesicle docking IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IMP
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IEA
 biological_processGO:0032940 secretion by cell IEA
 biological_processGO:0033605 positive regulation of catecholamine secretion IEA
 biological_processGO:0035493 SNARE complex assembly IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IGI
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0042641 actomyosin IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
 cellular_componentGO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity IMP
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0032028 myosin head/neck binding IEA
 molecular_functionGO:0043008 ATP-dependent protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Other interleukin signaling
LGI-ADAM interactions
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Stx1atm1Tfuj/Stx1a+
Genetic Background: B6.Cg-Stx1atm1Tfuj

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Stx1atm1Tfuj/Stx1a+
Genetic Background: B6.Cg-Stx1atm1Tfuj

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0002917 decreased synaptic depression "decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0003360 depression-related behavior 
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Allelic Composition: Clcn7tm1.1Mjec/Clcn7+
Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Stx1atm1Tfuj/Stx1a+
Genetic Background: B6.Cg-Stx1atm1Tfuj

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Stx1atm1Migar/Stx1a+
Genetic Background: involves: C57BL/6N

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx1atm1Migar/Stx1a+
Genetic Background: involves: C57BL/6N

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Stx1atm1Migar/Stx1a+
Genetic Background: involves: C57BL/6N

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Stx1atm1Tfuj/Stx1a+
Genetic Background: B6.Cg-Stx1atm1Tfuj

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx1atm1Migar/Stx1a+
Genetic Background: involves: C57BL/6N

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx1atm1Migar/Stx1a+
Genetic Background: involves: C57BL/6N

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdontm1Rsk/Cdontm1Rsk
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pcnatm1.1Mdsc/Pcnatm1.1Mdsc,Tg(Pcna*K164R)1Mdsc/0
Genetic Background: involves: FVB/N

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004626 Q64324 / Stxbp2 / syntaxin binding protein 2 / Q15833*  / complex
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex
 ENSMUSG00000027273 P60879 / Snap25 / Mus musculus synaptosomal-associated protein 25 (Snap25), transcript variant 4, mRNA. / P60880* / synaptosome associated protein 25*  / complex
 ENSMUSG00000033595 Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*  / reaction / complex
 ENSMUSG00000053841 Txlna / Q6PAM1 / taxilin alpha / P40222*  / complex / reaction






 

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