Manteia

ENSMUSG00000039232

Mus musculus

Features

Gene ID:	ENSMUSG00000039232

Biological name :	Stx11

Synonyms :	Stx11 / syntaxin 11

Possible biological names infered from orthology :	O75558

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	A2
Gene start:	12938209
Gene end:	12964298

Corresponding Affymetrix probe sets:	10367919 (MoGene1.0st) 1453228_at (Mouse Genome 430 2.0 Array) 1457780_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000151448 Ensembl peptide - ENSMUSP00000046243 Ensembl peptide - ENSMUSP00000132758 Ensembl peptide - ENSMUSP00000151223 NCBI entrez gene - 74732 See in Manteia. MGI - MGI:1921982 RefSeq - XM_006512888 RefSeq - NM_001163590 RefSeq - NM_001163591 RefSeq - NM_029075 RefSeq - XM_006512886 RefSeq - XM_006512887 RefSeq Peptide - NP_001157063 RefSeq Peptide - NP_083351 RefSeq Peptide - NP_001157062 swissprot - A0A1W2P6Y3 swissprot - Q3U5V8 swissprot - A0A1W2P6E3 Ensembl - ENSMUSG00000039232

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
stx11a	ENSDARG00000044039	Danio rerio
stx11b.1	ENSDARG00000029290	Danio rerio
stx11b.2	ENSDARG00000042231	Danio rerio
	ENSGALG00000011673	Gallus gallus
STX11	ENSG00000135604	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*	ENSMUSG00000047854	39
Stx1b / P61264 / Syntaxin-1B / P61266*	ENSMUSG00000030806	33
Stx2 / syntaxin 2 / P32856*	ENSMUSG00000029428	31
Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*	ENSMUSG00000007207	31
Stx3 / Q64704 / Syntaxin-3 / Q13277*	ENSMUSG00000041488	29
Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*	ENSMUSG00000030805	28
Gm379	ENSMUSG00000093916	21

Protein motifs (from Interpro)

Interpro ID	Name
IPR000727	Target SNARE coiled-coil homology domain
IPR006011	Syntaxin, N-terminal domain
IPR006012	Syntaxin/epimorphin, conserved site
IPR010989	SNARE
IPR028672	Syntaxin-11

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006886	intracellular protein transport	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
biological_process	GO:0061025	membrane fusion	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0005484	SNAP receptor activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0001505	hunched posture	"stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0002421	abnormal cell-mediated immunity	"abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0002463	abnormal neutrophil physiology	"abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0003945	abnormal lymphocyte physiology	"abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0005070	defective NK cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0005078	abnormal cytotoxic T cell physiology	"impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0005079	defective cytotoxic T cell cytolysis	"impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0005152	pancytopenia	"reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0008566	increased interferon-gamma secretion	"increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺ Genetic Background: involves: C57BL/6J * CBA/J
MP:0008577	increased circulating interferon-gamma level	"increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0008791	decreased NK cell degranulation	"reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}
MP:0011971	increased circulating lactate dehydrogenase level	"elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]	Show Allelic Composition: 1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}/0 Genetic Background: B6.FVB-1700016L21Rik^{Tg(Itgax-DTR/EGFP)57Lan}

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr