ENSMUSG00000030806


Mus musculus

Features
Gene ID: ENSMUSG00000030806
  
Biological name :Stx1b
  
Synonyms : P61264 / Stx1b / Syntaxin-1B
  
Possible biological names infered from orthology : P61266
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 127803900
Gene end: 127824549
  
Corresponding Affymetrix probe sets: 10568298 (MoGene1.0st)   1421673_s_at (Mouse Genome 430 2.0 Array)   1438780_at (Mouse Genome 430 2.0 Array)   1450349_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101874
Ensembl peptide - ENSMUSP00000145698
NCBI entrez gene - 56216     See in Manteia.
MGI - MGI:1930705
RefSeq - XM_011241866
RefSeq - NM_024414
RefSeq - XM_006508044
RefSeq Peptide - NP_077725
swissprot - P61264
swissprot - A0A0U1RNT8
Ensembl - ENSMUSG00000030806
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx1bENSDARG00000000503Danio rerio
 STX1BENSG00000099365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*ENSMUSG0000000720784
Stx2 / syntaxin 2 / P32856*ENSMUSG0000002942863
Stx3 / Q64704 / Syntaxin-3 / Q13277*ENSMUSG0000004148860
Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*ENSMUSG0000003080548
Stx11 / syntaxin 11 / O75558*ENSMUSG0000003923233
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*ENSMUSG0000004785428
Gm379ENSMUSG0000009391625


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR037016  Syntaxin-1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IGI
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006904 vesicle docking involved in exocytosis IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010807 regulation of synaptic vesicle priming IGI
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016081 synaptic vesicle docking IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IMP
 biological_processGO:0060025 regulation of synaptic activity ISS
 biological_processGO:0061669 spontaneous neurotransmitter secretion IMP
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
 biological_processGO:1903422 negative regulation of synaptic vesicle recycling IMP
 biological_processGO:1904050 positive regulation of spontaneous neurotransmitter secretion IMP
 biological_processGO:1905302 negative regulation of macropinocytosis ISS
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005652 nuclear lamina ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0098793 presynapse IMP
 cellular_componentGO:0099056 integral component of presynaptic membrane IC
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ryr2tm1.1Swch/Ryr2tm2.1Swch
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stx1btm1.1Sud/Stx1btm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

Allelic Composition: Stx1btm1.1Sud/Stx1btm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Stx1btm1.1Sud/Stx1btm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008504 abnormal adrenal chromaffin cell morphology "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stx1btm1.1Sud/Stx1btm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: B6.Cg-Stx1btm1Tmis

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Stx1atm1Tfuj/Stx1atm1Tfuj,Stx1btm1Tmis/Stx1btm1Tmis
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033595 Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*  / complex / reaction






 

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