ENSMUSG00000030805


Mus musculus

Features
Gene ID: ENSMUSG00000030805
  
Biological name :Stx4a
  
Synonyms : P70452 / Stx4a / Syntaxin-4
  
Possible biological names infered from orthology : Q12846 / STX4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127824294
Gene end: 127849019
  
Corresponding Affymetrix probe sets: 10557793 (MoGene1.0st)   1451573_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033075
Ensembl peptide - ENSMUSP00000112927
Ensembl peptide - ENSMUSP00000118034
NCBI entrez gene - 20909     See in Manteia.
MGI - MGI:893577
RefSeq - XM_006507543
RefSeq - NM_009294
RefSeq - XM_006507540
RefSeq - XM_006507541
RefSeq - XM_006507542
RefSeq - XM_006507539
RefSeq Peptide - NP_033320
swissprot - P70452
swissprot - D6RJ29
Ensembl - ENSMUSG00000030805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx4ENSDARG00000052518Danio rerio
 STX4ENSG00000103496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stx1b / P61264 / Syntaxin-1B / P61266*ENSMUSG0000003080646
Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*ENSMUSG0000000720744
Stx2 / syntaxin 2 / P32856*ENSMUSG0000002942841
Stx3 / Q64704 / Syntaxin-3 / Q13277*ENSMUSG0000004148838
Stx11 / syntaxin 11 / O75558*ENSMUSG0000003923227
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*ENSMUSG0000004785424
Gm379ENSMUSG0000009391621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0016079 synaptic vesicle exocytosis TAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017157 regulation of exocytosis ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0033194 response to hydroperoxide ISO
 biological_processGO:0035493 SNARE complex assembly IDA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0043085 positive regulation of catalytic activity ISO
 biological_processGO:0043311 positive regulation of eosinophil degranulation ISO
 biological_processGO:0045785 positive regulation of cell adhesion ISO
 biological_processGO:0048278 vesicle docking IBA
 biological_processGO:0048284 organelle fusion ISO
 biological_processGO:0050921 positive regulation of chemotaxis ISO
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISO
 biological_processGO:0060291 long-term synaptic potentiation ISO
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISO
 biological_processGO:2000010 positive regulation of protein localization to cell surface ISO
 cellular_componentGO:0000322 storage vacuole IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome ISO
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0031201 SNARE complex ISS
 cellular_componentGO:0035749 myelin sheath adaxonal region IDA
 cellular_componentGO:0036477 somatodendritic compartment ISO
 cellular_componentGO:0042581 specific granule ISO
 cellular_componentGO:0043197 dendritic spine ISO
 cellular_componentGO:0043219 lateral loop IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000149 SNARE binding IPI
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016230 sphingomyelin phosphodiesterase activator activity ISO


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
ER-Phagosome pathway
Clathrin derived vesicle budding
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / reaction / complex
 ENSMUSG00000027882 Q60770 / Stxbp3 / Syntaxin-binding protein 3 / O00186*  / complex
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex
 ENSMUSG00000027287 O09044 / Snap23 / synaptosomal-associated protein 23 / O00161* / synaptosome associated protein 23*  / complex / reaction
 ENSMUSG00000050965 Prkca / protein kinase C, alpha / P17252*  / reaction
 ENSMUSG00000052889 Prkcb / P68404 / protein kinase C, beta / P05771*  / reaction
 ENSMUSG00000050732 Vamp8 / vesicle-associated membrane protein 8 / Q9BV40*  / reaction / complex
 ENSMUSG00000053841 Txlna / Q6PAM1 / taxilin alpha / P40222*  / complex / reaction
 ENSMUSG00000078816 Prkcg / P63318 / protein kinase C, gamma / P05129*  / reaction






 

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