ENSMUSG00000027287


Mus musculus

Features
Gene ID: ENSMUSG00000027287
  
Biological name :Snap23
  
Synonyms : O09044 / Snap23 / synaptosomal-associated protein 23
  
Possible biological names infered from orthology : O00161 / synaptosome associated protein 23
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 120567671
Gene end: 120601255
  
Corresponding Affymetrix probe sets: 10475199 (MoGene1.0st)   1420896_at (Mouse Genome 430 2.0 Array)   1420897_at (Mouse Genome 430 2.0 Array)   1420898_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112138
Ensembl peptide - ENSMUSP00000106339
Ensembl peptide - ENSMUSP00000116935
Ensembl peptide - ENSMUSP00000121509
Ensembl peptide - ENSMUSP00000119652
Ensembl peptide - ENSMUSP00000028743
NCBI entrez gene - 20619     See in Manteia.
MGI - MGI:109356
RefSeq - XM_006499057
RefSeq - NM_001177792
RefSeq - NM_001177793
RefSeq - NM_009222
RefSeq - XM_006499054
RefSeq - XM_006499055
RefSeq - XM_006499056
RefSeq Peptide - NP_001171263
RefSeq Peptide - NP_001171264
RefSeq Peptide - NP_033248
swissprot - E9Q8A1
swissprot - B0R030
swissprot - B0R029
swissprot - O09044
swissprot - Q9D3L3
swissprot - A2AKH4
Ensembl - ENSMUSG00000027287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 snap23.1ENSDARG00000012874Danio rerio
 snap23.2ENSDARG00000055252Danio rerio
 SNAP23ENSGALG00000009097Gallus gallus
 O00161ENSG00000092531Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P60879 / Snap25 / Mus musculus synaptosomal-associated protein 25 (Snap25), transcript variant 4, mRNA. / P60880* / synaptosome associated protein 25*ENSMUSG0000002727354


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR000928  SNAP-25


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002553 histamine secretion by mast cell IEA
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016082 synaptic vesicle priming IBA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0042582 azurophil granule IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Clathrin derived vesicle budding
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp11cm1Btlr/Y,Tg(BCL2)22Wehi/0
Genetic Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Cnga2tm2Reed/Y
Genetic Background: involves: 129/Sv * BALB/cJ

Allelic Composition: Snap23tm1.1Paro/Snap23tm1.1Paro
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Snap23tm1.1Paro/Snap23tm1.1Paro
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / reaction / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / complex
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction / complex
 ENSMUSG00000050732 Vamp8 / vesicle-associated membrane protein 8 / Q9BV40*  / reaction / complex






 

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