ENSMUSG00000050732


Mus musculus

Features
Gene ID: ENSMUSG00000050732
  
Biological name :Vamp8
  
Synonyms : Vamp8 / vesicle-associated membrane protein 8
  
Possible biological names infered from orthology : Q9BV40
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 72385223
Gene end: 72390703
  
Corresponding Affymetrix probe sets: 10545409 (MoGene1.0st)   1420624_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059501
Ensembl peptide - ENSMUSP00000145955
NCBI entrez gene - 22320     See in Manteia.
MGI - MGI:1336882
RefSeq - NM_016794
RefSeq Peptide - NP_058074
swissprot - A0A0U1RPE8
swissprot - A0A0R4J0R1
Ensembl - ENSMUSG00000050732
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vamp8ENSDARG00000024116Danio rerio
 VAMP8ENSG00000118640Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*ENSMUSG0000002089437
Vamp1 / Q62442 / vesicle-associated membrane protein 1 / P23763*ENSMUSG0000003033733
Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*ENSMUSG0000002895532
Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*ENSMUSG0000002669627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016240 autophagosome membrane docking IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070254 mucus secretion IEA
 biological_processGO:0097352 autophagosome maturation IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 biological_processGO:1903531 negative regulation of secretion by cell IEA
 biological_processGO:1903595 positive regulation of histamine secretion by mast cell IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0035577 azurophil granule membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0098594 mucin granule IEA
 molecular_functionGO:0019869 chloride channel inhibitor activity IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: 129-Vamp8tm1.1Hong

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0004155 resistance to induced pancreatitis "reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: 129-Vamp8tm1.1Hong

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast/J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast/J

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0008804 abnormal circulating amylase level "any anomaly in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: 129-Vamp8tm1.1Hong

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0009160 abnormal pancreatic acinar cell zymogen granule "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

Allelic Composition: Vamp8tm1.1Hong/Vamp8tm1.1Hong
Genetic Background: B6.129P2-Vamp8tm1.1Hong

 MP:0011413 colorless urine "absence of the usual straw-coloration of the urine" [MGI:anna]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

 MP:0011885 abnormal circulating lipase level "any anomaly in the concentration of lipase in the blood, in particular the serum; the measurement of serum lipase activity is widely used for the diagnosis of acute pancreatitis" [MGI:csmith]
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Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: involves: C57BL/6NSlc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027287 O09044 / Snap23 / synaptosomal-associated protein 23 / O00161* / synaptosome associated protein 23*  / reaction / complex
 ENSMUSG00000039361 Picalm / Q7M6Y3 / Phosphatidylinositol-binding clathrin assembly protein / Q13492*  / complex / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction / complex






 

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