ENSMUSG00000028955


Mus musculus

Features
Gene ID: ENSMUSG00000028955
  
Biological name :Vamp3
  
Synonyms : P63024 / Vamp3 / vesicle-associated membrane protein 3
  
Possible biological names infered from orthology : Q15836
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 151047300
Gene end: 151057963
  
Corresponding Affymetrix probe sets: 10518805 (MoGene1.0st)   1421102_a_at (Mouse Genome 430 2.0 Array)   1433693_x_at (Mouse Genome 430 2.0 Array)   1433916_at (Mouse Genome 430 2.0 Array)   1437708_x_at (Mouse Genome 430 2.0 Array)   1456245_x_at (Mouse Genome 430 2.0 Array)   1457391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030797
NCBI entrez gene - 22319     See in Manteia.
MGI - MGI:1321389
RefSeq - NM_009498
RefSeq Peptide - NP_033524
swissprot - P63024
Ensembl - ENSMUSG00000028955
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vamp3ENSDARG00000070161Danio rerio
 VAMP3ENSGALG00000000579Gallus gallus
 VAMP3ENSG00000049245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*ENSMUSG0000002089472
Vamp1 / Q62442 / vesicle-associated membrane protein 1 / P23763*ENSMUSG0000003033771
Vamp8 / vesicle-associated membrane protein 8 / Q9BV40*ENSMUSG0000005073231
Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*ENSMUSG0000002669631


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0017156 calcium ion regulated exocytosis IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0035493 SNARE complex assembly IDA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0043001 Golgi to plasma membrane protein transport IMP
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:1903531 negative regulation of secretion by cell IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast/J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0011816 decreased pre-pro B cell number "reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0013414 decreased myeloid cell number in bone marrow "reduction in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0013684 increased early germinal center B cell number "increase in the number of germinal center B cells with residual expression of IgD" [MGI:Saran]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0013685 decreased late germinal center B cell number "reduction in the number of germinal center B cells expressing IgG1 and lacking expression of IgD" [MGI:Saran]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / reaction / complex
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / reaction / complex
 ENSMUSG00000023830 Igf2r / Q07113 / Cation-independent mannose-6-phosphate receptor / P11717* / insulin like growth factor 2 receptor*  / complex
 ENSMUSG00000007458 M6pr / P24668 / Cation-dependent mannose-6-phosphate receptor / P20645* / mannose-6-phosphate receptor, cation dependent*  / complex
 ENSMUSG00000027287 O09044 / Snap23 / synaptosomal-associated protein 23 / O00161* / synaptosome associated protein 23*  / complex
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000039361 Picalm / Q7M6Y3 / Phosphatidylinositol-binding clathrin assembly protein / Q13492*  / reaction / complex
 ENSMUSG00000070953 Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*  / complex
 ENSMUSG00000027522 Stx16 / Q8BVI5 / syntaxin 16 / O14662* / STX16-NPEPL1* / STX16-NPEPL1 readthrough (NMD candidate)*  / complex
 ENSMUSG00000024983 Vti1a / O89116 / vesicle transport through interaction with t-SNAREs 1A / Q96AJ9*  / complex






 

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