ENSMUSG00000023830


Mus musculus

Features
Gene ID: ENSMUSG00000023830
  
Biological name :Igf2r
  
Synonyms : Cation-independent mannose-6-phosphate receptor / Igf2r / Q07113
  
Possible biological names infered from orthology : insulin like growth factor 2 receptor / P11717
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 12682406
Gene end: 12769664
  
Corresponding Affymetrix probe sets: 10447799 (MoGene1.0st)   1424111_at (Mouse Genome 430 2.0 Array)   1424112_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124094
Ensembl peptide - ENSMUSP00000124679
Ensembl peptide - ENSMUSP00000124664
Ensembl peptide - ENSMUSP00000024599
NCBI entrez gene - 16004     See in Manteia.
MGI - MGI:96435
RefSeq - NM_010515
RefSeq Peptide - NP_034645
swissprot - A0A1C7ZN06
swissprot - F6SFP4
swissprot - E0CXV7
swissprot - Q07113
Ensembl - ENSMUSG00000023830
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf2rENSDARG00000006094Danio rerio
 IGF2RENSGALG00000011621Gallus gallus
 IGF2RENSG00000197081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000479  Cation-independent mannose-6-phosphate receptor
 IPR000562  Fibronectin type II domain
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR013806  Kringle-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0007041 lysosomal transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005641 nuclear envelope lumen IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030118 clathrin coat IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0001972 retinoic acid binding IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding ISS
 molecular_functionGO:0005520 insulin-like growth factor binding IPI
 molecular_functionGO:0005537 mannose binding IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2rtm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Brwd1Gt(AW0417)Wtsi/Brwd1Gt(AW0417)Wtsi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Dlx5tm1Levi/Dlx5tm1Levi
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001699 enlarged embryo size "larger proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1Stw/Igf2rtm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1Rlj/Igf2r+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

Allelic Composition: Igf2rtm1Rlj/Igf2r+,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

Allelic Composition: Igf2rtm1Rlj/Igf2r+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129/Sv * C57BL/6 * DBA

Allelic Composition: Igf2rtm1Rlj/Igf2r+,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0004199 enlarged fetal size "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2tm1Rob/Igf2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0004906 enlarged uterus 
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004920 increased placenta weight "increase in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0008258 thin endometrium "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009085 abnormal uterine horn morphology "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009087 dilated uterine horn "an expansion in the volume or area of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009097 absent endometrial glands "absence of the simple or branched tubular uterine glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0009432 increased fetal weight "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009673 increased birth weight "increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0009702 increased birth body size "increase in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0011030 impaired branching involved in preterminal bronchiole morphogenesis 
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6J * MF1

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igf2rtm1Wag/Igf2rtm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Igf2rtm1Stw/Igf2rtm1Stw
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Rr27tm1Tilg/Rr27+,Igf2tm1Rob/Igf2+,Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igf2rtm1Stw/Igf2r+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2rtm2Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * 129S/SvEv

Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igf2rtm1.1Rlj/Igf2r+
Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ntf3tm1Tojo/Ntf3tm1Tojo
Genetic Background: involves: C57BL/6 * DBA/2 * ICR

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Igf2rtm2Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

Allelic Composition: Igf2rtm1Arge/Igf2r+
Genetic Background: involves: 129/Sv * C57BL/6J * MF1

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

 MP:0011873 enlarged uterine horn "increased size of the uterine horn" [MGI:Colin_McKerlie]
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Allelic Composition: Igf2rtm1.1(IGF2R)Arte/Igf2r+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / complex
 ENSMUSG00000070953 Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*  / complex






 

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