ENSG00000049245


Homo sapiens

Features
Gene ID: ENSG00000049245
  
Biological name :VAMP3
  
Synonyms : Q15836 / VAMP3 / vesicle associated membrane protein 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.23
Gene start: 7771269
Gene end: 7781432
  
Corresponding Affymetrix probe sets: 201336_at (Human Genome U133 Plus 2.0 Array)   201337_s_at (Human Genome U133 Plus 2.0 Array)   211749_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000054666
Ensembl peptide - ENSP00000465820
NCBI entrez gene - 9341     See in Manteia.
OMIM - 603657
RefSeq - XM_017002841
RefSeq - NM_004781
RefSeq Peptide - NP_004772
swissprot - Q15836
swissprot - Q6FGG2
swissprot - K7EKX0
Ensembl - ENSG00000049245
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vamp3ENSDARG00000070161Danio rerio
 VAMP3ENSGALG00000000579Gallus gallus
 Vamp3ENSMUSG00000028955Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC129492.3ENSG0000026362075
VAMP2 / P63027 / vesicle associated membrane protein 2ENSG0000022020574
VAMP1 / P23763 / vesicle associated membrane protein 1ENSG0000013919070
VAMP4 / O75379 / vesicle associated membrane protein 4ENSG0000011753332
VAMP8 / Q9BV40 / vesicle associated membrane protein 8ENSG0000011864030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0006904 vesicle docking involved in exocytosis TAS
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0035493 SNARE complex assembly IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IDA
 biological_processGO:0043001 Golgi to plasma membrane protein transport IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061025 membrane fusion TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:1903531 negative regulation of secretion by cell IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane TAS
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000003056 M6PR / P20645 / mannose-6-phosphate receptor, cation dependent  / complex
 ENSG00000073969 NSF / P46459 / N-ethylmaleimide sensitive factor, vesicle fusing ATPase  / reaction / complex
 ENSG00000073921 PICALM / Q13492 / phosphatidylinositol binding clathrin assembly protein  / reaction / complex
 ENSG00000143952 VPS54 / Q9P1Q0 / VPS54, GARP complex subunit  / reaction
 ENSG00000136933 Q7Z6M1 / RABEPK / Rab9 effector protein with kelch motifs  / complex
 ENSG00000149823 VPS51 / Q9UID3 / VPS51, GARP complex subunit  / reaction
 ENSG00000123595 RAB9A / P51151 / RAB9A, member RAS oncogene family  / complex
 ENSG00000141252 VPS53 / Q5VIR6 / VPS53, GARP complex subunit  / reaction
 ENSG00000092531 O00161 / SNAP23 / synaptosome associated protein 23  / complex
 ENSG00000223501 VPS52 / Q8N1B4 / VPS52, GARP complex subunit  / reaction
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / complex / reaction
 ENSG00000105402 NAPA / P54920 / NSF attachment protein alpha  / reaction / complex
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / complex / reaction
 ENSG00000135968 GCC2 / Q8IWJ2 / GRIP and coiled-coil domain containing 2  / reaction
 ENSG00000197081 IGF2R / P11717 / insulin like growth factor 2 receptor  / complex
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / reaction / complex






 

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