ENSG00000003056


Homo sapiens

Features
Gene ID: ENSG00000003056
  
Biological name :M6PR
  
Synonyms : M6PR / mannose-6-phosphate receptor, cation dependent / P20645
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 8940363
Gene end: 8949955
  
Corresponding Affymetrix probe sets: 200900_s_at (Human Genome U133 Plus 2.0 Array)   200901_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444684
Ensembl peptide - ENSP00000442100
Ensembl peptide - ENSP00000442983
Ensembl peptide - ENSP00000000412
Ensembl peptide - ENSP00000437595
Ensembl peptide - ENSP00000439070
Ensembl peptide - ENSP00000439968
Ensembl peptide - ENSP00000440488
Ensembl peptide - ENSP00000440962
Ensembl peptide - ENSP00000441030
Ensembl peptide - ENSP00000441040
NCBI entrez gene - 4074     See in Manteia.
OMIM - 154540
RefSeq - XM_005253376
RefSeq - NM_001207024
RefSeq - NM_002355
RefSeq Peptide - NP_001193953
RefSeq Peptide - NP_002346
swissprot - H0YF90
swissprot - H0YFL0
swissprot - H0YFY9
swissprot - H0YGE9
swissprot - H0YGT2
swissprot - P20645
swissprot - F5GX30
swissprot - F5GXE0
swissprot - F5H4U1
swissprot - F5GXU0
swissprot - F5H883
Ensembl - ENSG00000003056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 m6prENSDARG00000018432Danio rerio
 M6PRENSGALG00000031681Gallus gallus
 M6prENSMUSG00000007458Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000296  Cation-dependent mannose-6-phosphate receptor
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR028927  Mannose-6-phosphate receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008333 endosome to lysosome transport TAS
 biological_processGO:0015761 mannose transmembrane transport IEA
 biological_processGO:0033299 secretion of lysosomal enzymes IEA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0000323 lytic vacuole IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0030904 retromer complex IPI
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0015578 mannose transmembrane transporter activity IEA
 molecular_functionGO:1905394 retromer complex binding IMP


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000223501 VPS52 / Q8N1B4 / VPS52, GARP complex subunit  / reaction
 ENSG00000141252 VPS53 / Q5VIR6 / VPS53, GARP complex subunit  / reaction
 ENSG00000123595 RAB9A / P51151 / RAB9A, member RAS oncogene family  / complex
 ENSG00000149823 VPS51 / Q9UID3 / VPS51, GARP complex subunit  / reaction
 ENSG00000049245 VAMP3 / Q15836 / vesicle associated membrane protein 3  / complex
 ENSG00000136933 Q7Z6M1 / RABEPK / Rab9 effector protein with kelch motifs  / complex
 ENSG00000003056 M6PR / P20645 / mannose-6-phosphate receptor, cation dependent  / complex
 ENSG00000143952 VPS54 / Q9P1Q0 / VPS54, GARP complex subunit  / reaction
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / reaction
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / reaction
 ENSG00000135968 GCC2 / Q8IWJ2 / GRIP and coiled-coil domain containing 2  / reaction
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / reaction






 

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