ENSG00000135968


Homo sapiens

Features
Gene ID: ENSG00000135968
  
Biological name :GCC2
  
Synonyms : GCC2 / GRIP and coiled-coil domain containing 2 / Q8IWJ2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q12.3
Gene start: 108448561
Gene end: 108509415
  
Corresponding Affymetrix probe sets: 202832_at (Human Genome U133 Plus 2.0 Array)   237565_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392470
Ensembl peptide - ENSP00000419969
Ensembl peptide - ENSP00000475798
Ensembl peptide - ENSP00000475234
Ensembl peptide - ENSP00000307939
Ensembl peptide - ENSP00000376996
Ensembl peptide - ENSP00000386997
Ensembl peptide - ENSP00000387350
NCBI entrez gene - 9648     See in Manteia.
OMIM - 612711
RefSeq - NM_181453
RefSeq - XM_006712870
RefSeq - XM_006712871
RefSeq - XM_006712872
RefSeq - XM_011512213
RefSeq Peptide - NP_852118
swissprot - U3KQE0
swissprot - Q8IWJ2
swissprot - B8ZZA5
swissprot - H7BYJ9
swissprot - H7C010
swissprot - B8ZZW2
swissprot - U3KPU4
Ensembl - ENSG00000135968
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ377903.3ENSDARG00000110024Danio rerio
 GCC2ENSGALG00000016806Gallus gallus
 Gcc2ENSMUSG00000038039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000237  GRIP domain
 IPR032023  GCC2, Rab binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006622 protein targeting to lysosome IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031023 microtubule organizing center organization IMP
 biological_processGO:0034067 protein localization to Golgi apparatus IMP
 biological_processGO:0034453 microtubule anchoring IMP
 biological_processGO:0034499 late endosome to Golgi transport IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0070861 regulation of protein exit from endoplasmic reticulum IMP
 biological_processGO:0071955 recycling endosome to Golgi transport IMP
 biological_processGO:0090161 Golgi ribbon formation IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / reaction
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / reaction
 ENSG00000049245 VAMP3 / Q15836 / vesicle associated membrane protein 3  / reaction
 ENSG00000143952 VPS54 / Q9P1Q0 / VPS54, GARP complex subunit  / reaction
 ENSG00000123595 RAB9A / P51151 / RAB9A, member RAS oncogene family  / reaction
 ENSG00000136933 Q7Z6M1 / RABEPK / Rab9 effector protein with kelch motifs  / reaction
 ENSG00000149823 VPS51 / Q9UID3 / VPS51, GARP complex subunit  / reaction
 ENSG00000141252 VPS53 / Q5VIR6 / VPS53, GARP complex subunit  / reaction
 ENSG00000003056 M6PR / P20645 / mannose-6-phosphate receptor, cation dependent  / reaction
 ENSG00000197081 IGF2R / P11717 / insulin like growth factor 2 receptor  / reaction
 ENSG00000135968 GCC2 / Q8IWJ2 / GRIP and coiled-coil domain containing 2  / complex
 ENSG00000223501 VPS52 / Q8N1B4 / VPS52, GARP complex subunit  / reaction
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / reaction






 

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