ENSG00000123595


Homo sapiens

Features
Gene ID: ENSG00000123595
  
Biological name :RAB9A
  
Synonyms : P51151 / RAB9A / RAB9A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 13689125
Gene end: 13710506
  
Corresponding Affymetrix probe sets: 221808_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420127
Ensembl peptide - ENSP00000490117
Ensembl peptide - ENSP00000480777
NCBI entrez gene - 9367     See in Manteia.
OMIM - 300284
RefSeq - NM_004251
RefSeq - XM_017029964
RefSeq - NM_001195328
RefSeq Peptide - NP_001182257
RefSeq Peptide - NP_004242
swissprot - A0A024RBV5
swissprot - P51151
swissprot - A0A1B0GUI0
Ensembl - ENSG00000123595
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab9aENSDARG00000045027Danio rerio
 RAB9AENSGALG00000016579Gallus gallus
 Rab9ENSMUSG00000079316Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB9B / Q9NP90 / RAB9B, member RAS oncogene familyENSG0000012357076
RAB7A / P51149 / RAB7A, member RAS oncogene familyENSG0000007578551
RAB7B / Q96AH8 / RAB7B, member RAS oncogene familyENSG0000027660040
RAB23 / Q9ULC3 / RAB23, member RAS oncogene familyENSG0000011221033
RAB32 / Q13637 / RAB32, member RAS oncogene familyENSG0000011850832
RAB29 / O14966 / RAB29, member RAS oncogene familyENSG0000011728031
RAB38 / P57729 / RAB38, member RAS oncogene familyENSG0000012389230


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IBA
 biological_processGO:0045921 positive regulation of exocytosis IMP
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0042470 melanosome ISS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000003056 M6PR / P20645 / mannose-6-phosphate receptor, cation dependent  / complex
 ENSG00000049245 VAMP3 / Q15836 / vesicle associated membrane protein 3  / complex
 ENSG00000149823 VPS51 / Q9UID3 / VPS51, GARP complex subunit  / reaction
 ENSG00000141252 VPS53 / Q5VIR6 / VPS53, GARP complex subunit  / reaction
 ENSG00000223501 VPS52 / Q8N1B4 / VPS52, GARP complex subunit  / reaction
 ENSG00000143952 VPS54 / Q9P1Q0 / VPS54, GARP complex subunit  / reaction
 ENSG00000104915 STX10 / O60499 / syntaxin 10  / reaction
 ENSG00000136933 Q7Z6M1 / RABEPK / Rab9 effector protein with kelch motifs  / complex
 ENSG00000146966 Q9ULE3 / DENND2A / DENN domain containing 2A  / reaction
 ENSG00000124222 STX16 / O14662 / syntaxin 16  / reaction
 ENSG00000135968 GCC2 / Q8IWJ2 / GRIP and coiled-coil domain containing 2  / reaction
 ENSG00000197081 IGF2R / P11717 / insulin like growth factor 2 receptor  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000151532 VTI1A / Q96AJ9 / vesicle transport through interaction with t-SNAREs 1A  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr