ENSG00000146966


Homo sapiens

Features
Gene ID: ENSG00000146966
  
Biological name :DENND2A
  
Synonyms : DENND2A / DENN domain containing 2A / Q9ULE3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q34
Gene start: 140518420
Gene end: 140673993
  
Corresponding Affymetrix probe sets: 221885_at (Human Genome U133 Plus 2.0 Array)   221886_at (Human Genome U133 Plus 2.0 Array)   53991_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419464
Ensembl peptide - ENSP00000419654
Ensembl peptide - ENSP00000442245
Ensembl peptide - ENSP00000420605
Ensembl peptide - ENSP00000420145
Ensembl peptide - ENSP00000275884
Ensembl peptide - ENSP00000417673
Ensembl peptide - ENSP00000418088
Ensembl peptide - ENSP00000418760
Ensembl peptide - ENSP00000418844
NCBI entrez gene - 27147     See in Manteia.
RefSeq - XM_017011989
RefSeq - NM_001318052
RefSeq - NM_001318053
RefSeq - NM_015689
RefSeq - XM_005249977
RefSeq - XM_005249979
RefSeq - XM_011516052
RefSeq - XM_011516053
RefSeq - XM_011516054
RefSeq Peptide - NP_056504
RefSeq Peptide - NP_001304982
RefSeq Peptide - NP_001304981
swissprot - C9IYZ8
swissprot - F8WAT8
swissprot - H7C5K8
swissprot - Q9ULE3
swissprot - C9IY76
swissprot - C9JD15
swissprot - C9JAA0
Ensembl - ENSG00000146966
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DENND2AENSGALG00000012857Gallus gallus
 Q8C4S8ENSMUSG00000038456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ST5 / P78524 / suppression of tumorigenicity 5ENSG0000016644450
Q68D51 / DENND2C / DENN domain containing 2CENSG0000017598443
Q9H6A0 / DENND2D / DENN domain containing 2DENSG0000016277722
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448514
O75064 / DENND4B / DENN domain containing 4BENSG0000019883714
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714514
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952213
Q6P3S1 / DENND1B / DENN domain containing 1BENSG0000021304712
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401411
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045611
Q8IV53 / DENND1C / DENN domain containing 1CENSG0000020574411
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051410
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533910


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000123595 RAB9A / P51151 / RAB9A, member RAS oncogene family  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction






 

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