ENSG00000105339


Homo sapiens

Features
Gene ID: ENSG00000105339
  
Biological name :DENND3
  
Synonyms : A2RUS2 / DENND3 / DENN domain containing 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.3
Gene start: 141117278
Gene end: 141195808
  
Corresponding Affymetrix probe sets: 212974_at (Human Genome U133 Plus 2.0 Array)   212975_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428276
Ensembl peptide - ENSP00000430912
Ensembl peptide - ENSP00000430786
Ensembl peptide - ENSP00000430695
Ensembl peptide - ENSP00000430625
Ensembl peptide - ENSP00000429780
Ensembl peptide - ENSP00000429725
Ensembl peptide - ENSP00000429533
Ensembl peptide - ENSP00000428714
Ensembl peptide - ENSP00000428641
Ensembl peptide - ENSP00000262585
Ensembl peptide - ENSP00000410594
Ensembl peptide - ENSP00000428155
NCBI entrez gene - 22898     See in Manteia.
OMIM - 617503
RefSeq - XM_017013243
RefSeq - NM_001352890
RefSeq - NM_014957
RefSeq - XM_005250838
RefSeq - XM_005250839
RefSeq - XM_005250840
RefSeq - XM_005250841
RefSeq - XM_005250842
RefSeq - XM_011516933
RefSeq - XM_011516934
RefSeq - XM_011516937
RefSeq - XM_017013241
RefSeq - XM_017013242
RefSeq Peptide - NP_001339819
RefSeq Peptide - NP_055772
swissprot - E5RI43
swissprot - E5RHH2
swissprot - E5RH95
swissprot - B3KRG7
swissprot - E9PF32
swissprot - E5RJ42
swissprot - H0YAW2
swissprot - H0YAY3
swissprot - H0YBH5
swissprot - H0YBK9
swissprot - A2RUS2
swissprot - E5RIR7
Ensembl - ENSG00000105339
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd3aENSDARG00000078797Danio rerio
 dennd3bENSDARG00000013153Danio rerio
 DENND3ENSGALG00000031380Gallus gallus
 A2RT67ENSMUSG00000036661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448516
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714515
O75064 / DENND4B / DENN domain containing 4BENSG0000019883714
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045613
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401412
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051411
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952211
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759849
ST5 / P78524 / suppression of tumorigenicity 5ENSG000001664449
Q8IV53 / DENND1C / DENN domain containing 1CENSG000002057449
Q6P3S1 / DENND1B / DENN domain containing 1BENSG000002130479
Q9ULE3 / DENND2A / DENN domain containing 2AENSG000001469668
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627777


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR001680  WD40 repeat
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008333 endosome to lysosome transport ISS
 biological_processGO:0044257 cellular protein catabolic process ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000206418 RAB12 / Q6IQ22 / RAB12, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction






 

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