ENSG00000177169


Homo sapiens

Features
Gene ID: ENSG00000177169
  
Biological name :ULK1
  
Synonyms : O75385 / ULK1 / unc-51 like autophagy activating kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.33
Gene start: 131894651
Gene end: 131923167
  
Corresponding Affymetrix probe sets: 209333_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324560
NCBI entrez gene - 8408     See in Manteia.
OMIM - 603168
RefSeq - XM_011538799
RefSeq - NM_003565
RefSeq - XM_011538798
RefSeq Peptide - NP_003556
swissprot - O75385
Ensembl - ENSG00000177169
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ulk1aENSDARG00000062518Danio rerio
 ulk1bENSDARG00000074481Danio rerio
 ULK1ENSGALG00000002403Gallus gallus
 Ulk1ENSMUSG00000029512Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ULK2 / Q8IYT8 / unc-51 like autophagy activating kinase 2ENSG0000008329053
ULK3 / Q6PHR2 / unc-51 like kinase 3ENSG0000014047416
IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit betaENSG0000010436514
IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilonENSG0000026352814
CHUK / O15111 / conserved helix-loop-helix ubiquitous kinaseENSG0000021334113
TBK1 / Q9UHD2 / TANK binding kinase 1ENSG0000018373511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016237  Serine/threonine-protein kinase, Ulk1/Ulk2
 IPR017441  Protein kinase, ATP binding site
 IPR022708  Serine/threonine-protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0006914 autophagy ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0031102 neuron projection regeneration IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IDA
 biological_processGO:0031669 cellular response to nutrient levels ISS
 biological_processGO:0042594 response to starvation ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048675 axon extension IBA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IGI
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0000407 phagophore assembly site IEA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IDA
 cellular_componentGO:0034045 phagophore assembly site membrane IDA
 cellular_componentGO:0055037 recycling endosome TAS
 cellular_componentGO:0097629 extrinsic component of omegasome membrane IDA
 cellular_componentGO:0097632 extrinsic component of phagophore assembly site membrane IDA
 cellular_componentGO:0097635 extrinsic component of autophagosome membrane IDA
 cellular_componentGO:1990316 Atg1/ULK1 kinase complex IPI
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction / complex
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / complex / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / complex / reaction
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / complex / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction / complex
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction / complex
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex
 ENSG00000185236 Q15907 / RAB11B / RAB11B, member RAS oncogene family  / complex / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction
 ENSG00000132405 Q9P2M4 / TBC1D14 / TBC1 domain family member 14  / complex / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / complex / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction / complex
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000105339 A2RUS2 / DENND3 / DENN domain containing 3  / reaction






 

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