ENSG00000167965


Homo sapiens

Features
Gene ID: ENSG00000167965
  
Biological name :MLST8
  
Synonyms : MLST8 / MTOR associated protein, LST8 homolog / Q9BVC4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 2204248
Gene end: 2209416
  
Corresponding Affymetrix probe sets: 220587_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457870
Ensembl peptide - ENSP00000456944
Ensembl peptide - ENSP00000459612
Ensembl peptide - ENSP00000301724
Ensembl peptide - ENSP00000371888
Ensembl peptide - ENSP00000380313
Ensembl peptide - ENSP00000454235
Ensembl peptide - ENSP00000454629
Ensembl peptide - ENSP00000454698
Ensembl peptide - ENSP00000455046
Ensembl peptide - ENSP00000455458
Ensembl peptide - ENSP00000455475
Ensembl peptide - ENSP00000455642
Ensembl peptide - ENSP00000455850
Ensembl peptide - ENSP00000456046
Ensembl peptide - ENSP00000456063
Ensembl peptide - ENSP00000456076
Ensembl peptide - ENSP00000456405
NCBI entrez gene - 64223     See in Manteia.
OMIM - 612190
RefSeq - XM_017023552
RefSeq - NM_001199173
RefSeq - NM_001199174
RefSeq - NM_001199175
RefSeq - NM_001352057
RefSeq - NM_022372
RefSeq - XM_005255475
RefSeq - XM_005255478
RefSeq - XM_005255479
RefSeq - XM_017023548
RefSeq - XM_017023549
RefSeq - XM_017023551
RefSeq Peptide - NP_071767
RefSeq Peptide - NP_001186102
RefSeq Peptide - NP_001186103
RefSeq Peptide - NP_001186104
RefSeq Peptide - NP_001338986
swissprot - H3BM50
swissprot - H3BN58
swissprot - H3BPT1
swissprot - H3BPU5
swissprot - H3BQ74
swissprot - H3BR25
swissprot - H3BR38
swissprot - Q9BVC4
swissprot - A0A0A0MR05
swissprot - H3BSZ4
swissprot - I3L2E7
Ensembl - ENSG00000167965
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mlst8ENSDARG00000003167Danio rerio
 MLST8ENSGALG00000005878Gallus gallus
 Mlst8ENSMUSG00000024142Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037588  Target of rapamycin complex subunit LST8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031929 TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0032148 activation of protein kinase B activity TAS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0038202 TORC1 signaling IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031931 TORC1 complex IDA
 cellular_componentGO:0031932 TORC2 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / reaction / complex
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction / complex
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / reaction / complex
 ENSG00000179632 MAF1 / Q9H063 / MAF1 homolog, negative regulator of RNA polymerase III  / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / complex / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction / complex
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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