Manteia

ENSG00000166913

Homo sapiens

Features

Gene ID:	ENSG00000166913

Biological name :	YWHAB

Synonyms :	P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta / YWHAB

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	20
Strand:	1
Band:	q13.12
Gene start:	44885676
Gene end:	44908532

Corresponding Affymetrix probe sets:	208743_s_at (Human Genome U133 Plus 2.0 Array) 217717_s_at (Human Genome U133 Plus 2.0 Array) 217718_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000394729 Ensembl peptide - ENSP00000394558 Ensembl peptide - ENSP00000487924 Ensembl peptide - ENSP00000488178 Ensembl peptide - ENSP00000300161 Ensembl peptide - ENSP00000361930 NCBI entrez gene - 7529 See in Manteia. OMIM - 601289 RefSeq - XM_017028040 RefSeq - NM_003404 RefSeq - NM_139323 RefSeq - XM_017028039 RefSeq Peptide - NP_003395 RefSeq Peptide - NP_647539 swissprot - P31946 swissprot - Q4VY19 swissprot - Q4VY20 swissprot - A0A0J9YWZ2 swissprot - V9HWD6 swissprot - A0A0J9YWE8 Ensembl - ENSG00000166913

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
Q5PRD0	ENSDARG00000013078	Danio rerio
ywhabb	ENSDARG00000075758	Danio rerio
YWHAB	ENSGALG00000004143	Gallus gallus
Ywhab	ENSMUSG00000018326	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	ENSG00000164924	87
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	ENSG00000134308	81
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	ENSG00000128245	75
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	ENSG00000170027	75
SFN / P31947 / stratifin	ENSG00000175793	67
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	ENSG00000108953	66

Protein motifs (from Interpro)

Interpro ID	Name
IPR000308	14-3-3 protein
IPR023409	14-3-3 protein, conserved site
IPR023410	14-3-3 domain
IPR036815	14-3-3 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0006605	protein targeting	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0035308	negative regulation of protein dephosphorylation	IDA
biological_process	GO:0035329	hippo signaling	TAS
biological_process	GO:0043085	positive regulation of catalytic activity	IDA
biological_process	GO:0043488	regulation of mRNA stability	TAS
biological_process	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	IMP
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	IEA
biological_process	GO:0051220	cytoplasmic sequestering of protein	IDA
biological_process	GO:0051291	protein heterooligomerization	IEA
biological_process	GO:0061024	membrane organization	TAS
biological_process	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005925	focal adhesion	HDA
cellular_component	GO:0016020	membrane	HDA
cellular_component	GO:0017053	transcriptional repressor complex	IEA
cellular_component	GO:0030659	cytoplasmic vesicle membrane	TAS
cellular_component	GO:0042470	melanosome	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IDA
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008022	protein C-terminus binding	IEA
molecular_function	GO:0019899	enzyme binding	IPI
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0042802	identical protein binding	IPI
molecular_function	GO:0042826	histone deacetylase binding	IPI
molecular_function	GO:0045296	cadherin binding	IDA
molecular_function	GO:0050815	phosphoserine residue binding	IPI
molecular_function	GO:0051219	phosphoprotein binding	IPI

Pathways (from Reactome)

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000011485	PPP5C / P53041 / protein phosphatase 5 catalytic subunit	/ reaction
ENSG00000100030	MAPK1 / P28482 / mitogen-activated protein kinase 1	/ reaction / complex
ENSG00000075413	MARK3 / P27448 / microtubule affinity regulating kinase 3	/ complex / reaction
ENSG00000132155	RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase	/ reaction / complex
ENSG00000126934	MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2	/ complex / reaction
ENSG00000089220	PEBP1 / P30086 / phosphatidylethanolamine binding protein 1	/ complex / reaction
ENSG00000102882	MAPK3 / P27361 / mitogen-activated protein kinase 3	/ complex / reaction
ENSG00000133703	KRAS / P01116 / KRAS proto-oncogene, GTPase	/ complex / reaction
ENSG00000078061	ARAF / P10398 / A-Raf proto-oncogene, serine/threonine kinase	/ reaction / complex
ENSG00000137693	YAP1 / P46937 / Yes associated protein 1	/ complex / reaction
ENSG00000174775	HRAS / P01112 / HRas proto-oncogene, GTPase	/ reaction / complex
ENSG00000141068	KSR1 / Q8IVT5 / kinase suppressor of ras 1	/ reaction / complex
ENSG00000169032	MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1	/ reaction / complex
ENSG00000157764	BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase	/ complex / reaction
ENSG00000132359	Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2	/ reaction / complex
ENSG00000177058	Q8NBW4 / SLC38A9 / solute carrier family 38 member 9	/ reaction / complex
ENSG00000106615	RHEB / Q15382 / Ras homolog, mTORC1 binding	/ complex / reaction
ENSG00000116473	RAP1A / P62834 / RAP1A, member of RAS oncogene family	/ complex / reaction
ENSG00000083750	RRAGB / Q5VZM2 / Ras related GTP binding B	/ complex / reaction
ENSG00000185650	Q07352 / ZFP36L1 / ZFP36 ring finger protein like 1	/ reaction / complex
ENSG00000083312	TNPO1 / Q92973 / transportin 1	/ reaction / complex
ENSG00000025039	RRAGD / Q9NQL2 / Ras related GTP binding D	/ complex / reaction
ENSG00000198793	MTOR / P42345 / mechanistic target of rapamycin kinase	/ complex / reaction
ENSG00000167193	CRK / P46108 / CRK proto-oncogene, adaptor protein	/ reaction / complex
ENSG00000155876	RRAGA / Q7L523 / Ras related GTP binding A	/ reaction / complex
ENSG00000167965	MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog	/ complex / reaction
ENSG00000134259	NGF / P01138 / nerve growth factor	/ reaction / complex
ENSG00000204673	AKT1S1 / Q96B36 / AKT1 substrate 1	/ complex / reaction
ENSG00000166913	YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	/ complex
ENSG00000116954	RRAGC / Q9HB90 / Ras related GTP binding C	/ reaction / complex
ENSG00000198400	NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1	/ complex / reaction
ENSG00000134313	Q9ULH0 / KIDINS220 / kinase D interacting substrate 220	/ reaction / complex
ENSG00000213281	NRAS / P01111 / NRAS proto-oncogene, GTPase	/ reaction / complex
ENSG00000141564	RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr