ENSG00000011485


Homo sapiens

Features
Gene ID: ENSG00000011485
  
Biological name :PPP5C
  
Synonyms : P53041 / PPP5C / protein phosphatase 5 catalytic subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 46346994
Gene end: 46392981
  
Corresponding Affymetrix probe sets: 201979_s_at (Human Genome U133 Plus 2.0 Array)   215705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375786
Ensembl peptide - ENSP00000434329
Ensembl peptide - ENSP00000012443
NCBI entrez gene - 5536     See in Manteia.
OMIM - 600658
RefSeq - XM_017026935
RefSeq - NM_001204284
RefSeq - NM_006247
RefSeq Peptide - NP_001191213
RefSeq Peptide - NP_006238
swissprot - P53041
swissprot - A0A024R0Q7
swissprot - A8MU39
swissprot - H0YDU8
Ensembl - ENSG00000011485
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp5cENSDARG00000034313Danio rerio
 Ppp5cENSMUSG00000003099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPEF2 / O14830 / protein phosphatase with EF-hand domain 2ENSG0000015619429
PPEF1 / O14829 / protein phosphatase with EF-hand domain 1ENSG0000008671727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR011236  Serine/threonine protein phosphatase 5
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013235  PPP domain
 IPR019734  Tetratricopeptide repeat
 IPR027363  Methylthioribose-1-phosphate isomerase, N-terminal
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010288 response to lead ion ISS
 biological_processGO:0016576 histone dephosphorylation IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation TAS
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1904550 response to arachidonic acid ISS
 biological_processGO:2000324 positive regulation of glucocorticoid receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:1990635 proximal dendrite IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISS
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IPI


Pathways (from Reactome)
Pathway description
Negative regulation of MAPK pathway
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction






 

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