ENSG00000169139


Homo sapiens

Features
Gene ID: ENSG00000169139
  
Biological name :UBE2V2
  
Synonyms : Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q11.21
Gene start: 48008400
Gene end: 48064708
  
Corresponding Affymetrix probe sets: 209096_at (Human Genome U133 Plus 2.0 Array)   228734_at (Human Genome U133 Plus 2.0 Array)   230411_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429886
Ensembl peptide - ENSP00000430019
Ensembl peptide - ENSP00000430741
Ensembl peptide - ENSP00000430491
Ensembl peptide - ENSP00000428209
Ensembl peptide - ENSP00000428818
Ensembl peptide - ENSP00000429419
NCBI entrez gene - 7336     See in Manteia.
OMIM - 603001
RefSeq - XM_017013808
RefSeq - NM_003350
RefSeq - XM_005251300
RefSeq - XM_011517583
RefSeq Peptide - NP_003341
swissprot - E5RIF1
swissprot - H0YBX6
swissprot - A0M8W4
swissprot - G3V113
swissprot - H0YBP9
swissprot - Q15819
Ensembl - ENSG00000169139
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PEH5ENSDARG00000028198Danio rerio
 Q5F3Z3ENSGALG00000028133Gallus gallus
 Q9D2M8ENSMUSG00000022674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1ENSG0000024468788


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0000729 DNA double-strand break processing IMP
 biological_processGO:0006282 regulation of DNA repair TAS
 biological_processGO:0006301 postreplication repair IBA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0042275 error-free postreplication DNA repair IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IBA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0031372 UBC13-MMS2 complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / complex / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction / complex
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction / complex
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction / complex
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex / reaction
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / complex / reaction
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction / complex
 ENSG00000066135 KDM4A / O75164 / lysine demethylase 4A  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction / complex
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000087206 UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / complex / reaction
 ENSG00000071794 HLTF / Q14527 / helicase like transcription factor  / reaction / complex
 ENSG00000146414 SHPRH / Q149N8 / SNF2 histone linker PHD RING helicase  / reaction / complex
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction






 

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