ENSG00000157212


Homo sapiens

Features
Gene ID: ENSG00000157212
  
Biological name :PAXIP1
  
Synonyms : PAX interacting protein 1 / PAXIP1 / Q6ZW49
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q36.2
Gene start: 154943687
Gene end: 155003084
  
Corresponding Affymetrix probe sets: 212825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380376
Ensembl peptide - ENSP00000384048
Ensembl peptide - ENSP00000389849
Ensembl peptide - ENSP00000392011
NCBI entrez gene - 22976     See in Manteia.
OMIM - 608254
RefSeq - XM_017011881
RefSeq - NM_007349
RefSeq - XM_005249539
RefSeq - XM_011515982
RefSeq - XM_011515983
RefSeq Peptide - NP_031375
swissprot - H7BZI8
swissprot - F8WC23
swissprot - Q6ZW49
Ensembl - ENSG00000157212
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 paxip1ENSDARG00000005606Danio rerio
 PAXIP1ENSGALG00000036064Gallus gallus
 Paxip1ENSMUSG00000002221Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MDC1 / Q14676 / mediator of DNA damage checkpoint 1ENSG0000013733713


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000416 positive regulation of histone H3-K36 methylation ISS
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 biological_processGO:0035066 positive regulation of histone acetylation ISS
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045830 positive regulation of isotype switching ISS
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0051568 histone H3-K4 methylation IDA
 biological_processGO:0051571 positive regulation of histone H3-K4 methylation ISS
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter ISS
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0060717 chorion development IEA
 biological_processGO:1902749 regulation of cell cycle G2/M phase transition IEA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 cellular_componentGO:0044666 MLL3/4 complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex / reaction
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / reaction / complex
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction / complex
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction / complex
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr