ENSG00000276180


Homo sapiens

Features
Gene ID: ENSG00000276180
  
Biological name :HIST1H4I
  
Synonyms : HIST1H4I / histone cluster 1 H4 family member i / P62805
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.1
Gene start: 27138588
Gene end: 27139881
  
Corresponding Affymetrix probe sets: 208181_at (Human Genome U133 Plus 2.0 Array)   214634_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481486
NCBI entrez gene - 8294     See in Manteia.
OMIM - 602833
RefSeq - NM_003495
RefSeq Peptide - NP_003486
swissprot - B2R4R0
swissprot - P62805
Ensembl - ENSG00000276180
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX323062.1ENSDARG00000115201Danio rerio
 HIST1H4IENSDARG00000110812Danio rerio
 P62806ENSMUSG00000060639Mus musculus
 P62806ENSMUSG00000064288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62805 / HIST2H4A / histone cluster 2 H4 family member aENSG00000270882100
P62805 / HIST1H4A / histone cluster 1 H4 family member aENSG00000278637100
P62805 / HIST1H4H / histone cluster 1 H4 family member hENSG00000158406100
P62805 / HIST1H4B / histone cluster 1 H4 family member bENSG00000278705100
P62805 / HIST1H4J / histone cluster 1 H4 family member jENSG00000197238100
P62805 / HIST1H4C / histone cluster 1 H4 family member cENSG00000197061100
P62805 / HIST4H4 / histone cluster 4 H4ENSG00000197837100
P62805 / HIST1H4K / histone cluster 1 H4 family member kENSG00000273542100
P62805 / HIST2H4B / histone cluster 2 H4 family member bENSG00000270276100
P62805 / HIST1H4E / histone cluster 1 H4 family member eENSG00000276966100
P62805 / HIST1H4D / histone cluster 1 H4 family member dENSG00000277157100
P62805 / HIST1H4F / histone cluster 1 H4 family member fENSG00000274618100
P62805 / HIST1H4L / histone cluster 1 H4 family member lENSG00000275126100
Q99525 / HIST1H4G / histone cluster 1 H4 family member gENSG0000027566380


Protein motifs (from Interpro)
Interpro ID Name
 IPR001951  Histone H4
 IPR004823  TATA box binding protein associated factor (TAF)
 IPR009072  Histone-fold
 IPR019809  Histone H4, conserved site
 IPR035425  CENP-T/Histone H4, histone fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly IDA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IDA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0016233 telomere capping TAS
 biological_processGO:0032200 telomere organization TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IDA
 biological_processGO:0045814 negative regulation of gene expression, epigenetic TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000786 nucleosome TAS
 cellular_componentGO:0000788 nuclear nucleosome IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000011485 PPP5C / P53041 / protein phosphatase 5 catalytic subunit  / reaction
 ENSG00000127663 KDM4B / O94953 / lysine demethylase 4B  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / reaction / complex
 ENSG00000103510 KAT8 / Q9H7Z6 / lysine acetyltransferase 8  / reaction
 ENSG00000116833 NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2  / complex
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / reaction / complex
 ENSG00000080345 RIF1 / Q5UIP0 / replication timing regulatory factor 1  / complex / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / reaction / complex
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / complex
 ENSG00000132703 APCS / P02743 / amyloid P component, serum  / reaction / complex
 ENSG00000128708 HAT1 / O14929 / histone acetyltransferase 1  / reaction
 ENSG00000132510 KDM6B / O15054 / lysine demethylase 6B  / reaction
 ENSG00000133247 KMT5C / Q86Y97 / lysine methyltransferase 5C  / reaction
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction
 ENSG00000134014 ELP3 / Q9H9T3 / elongator acetyltransferase complex subunit 3  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000074266 EED / O75530 / embryonic ectoderm development  / reaction / complex
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000138795 LEF1 / Q9UJU2 / lymphoid enhancer binding factor 1  / reaction
 ENSG00000139351 SYCP3 / Q8IZU3 / synaptonemal complex protein 3  / complex
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000163832 ELP6 / Q0PNE2 / elongator acetyltransferase complex subunit 6  / reaction
 ENSG00000110066 KMT5B / Q4FZB7 / lysine methyltransferase 5B  / reaction
 ENSG00000166313 APBB1 / O00213 / amyloid beta precursor protein binding family B member 1  / complex / reaction
 ENSG00000070495 JMJD6 / Q6NYC1 / arginine demethylase and lysine hydroxylase  / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000005302 MSL3 / Q8N5Y2 / MSL complex subunit 3  / reaction
 ENSG00000171940 O75362 / ZNF217 / zinc finger protein 217  / complex
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / reaction
 ENSG00000164256 PRDM9 / Q9NQV7 / PR/SET domain 9  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000174579 MSL2 / Q9HCI7 / MSL complex subunit 2  / reaction
 ENSG00000153147 O60264 / SMARCA5 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5  / complex / reaction
 ENSG00000048649 RSF1 / Q96T23 / remodeling and spacing factor 1  / complex
 ENSG00000167548 KMT2D / O14686 / lysine methyltransferase 2D  / reaction
 ENSG00000148737 Q9NQB0 / TCF7L2 / transcription factor 7 like 2  / reaction
 ENSG00000178691 SUZ12 / Q15022 / SUZ12 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000009954 BAZ1B / Q9UIG0 / bromodomain adjacent to zinc finger domain 1B  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000130816 DNMT1 / P26358 / DNA methyltransferase 1  / reaction / complex
 ENSG00000101945 O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1  / reaction / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000106462 EZH2 / Q15910 / enhancer of zeste 2 polycomb repressive complex 2 subunit  / reaction / complex
 ENSG00000188895 MSL1 / Q68DK7 / male specific lethal 1 homolog  / reaction
 ENSG00000172943 PHF8 / Q9UPP1 / PHD finger protein 8  / reaction / complex
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000102054 RBBP7 / Q16576 / RB binding protein 7, chromatin remodeling factor  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction / complex
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction / complex
 ENSG00000175792 Q9Y265 / RUVBL1 / RuvB like AAA ATPase 1  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex / reaction
 ENSG00000183955 KMT5A / Q9NQR1 / lysine methyltransferase 5A  / reaction
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / complex / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000196419 XRCC6 / P12956 / X-ray repair cross complementing 6  / reaction
 ENSG00000134759 ELP2 / Q6IA86 / elongator acetyltransferase complex subunit 2  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / reaction / complex
 ENSG00000196074 SYCP2 / Q9BX26 / synaptonemal complex protein 2  / complex
 ENSG00000196367 TRRAP / Q9Y4A5 / transformation/transcription domain associated protein  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction / complex
 ENSG00000170291 ELP5 / Q8TE02 / elongator acetyltransferase complex subunit 5  / reaction
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction
 ENSG00000128513 POT1 / Q9NUX5 / protection of telomeres 1  / reaction / complex
 ENSG00000152457 Q96SD1 / DCLRE1C / DNA cross-link repair 1C  / reaction / complex
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / complex / reaction
 ENSG00000109911 ELP4 / Q96EB1 / elongator acetyltransferase complex subunit 4  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / complex / reaction
 ENSG00000158161 EYA3 / Q99504 / EYA transcriptional coactivator and phosphatase 3  / reaction
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / complex
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex
 ENSG00000169083 AR / P10275 / androgen receptor  / complex / reaction
 ENSG00000070061 ELP1 / O95163 / elongator complex protein 1  / reaction
 ENSG00000181090 EHMT1 / Q9H9B1 / euchromatic histone lysine methyltransferase 1  / reaction
 ENSG00000162521 RBBP4 / Q09028 / RB binding protein 4, chromatin remodeling factor  / reaction / complex
 ENSG00000198890 PRMT6 / Q96LA8 / protein arginine methyltransferase 6  / reaction / complex
 ENSG00000066135 KDM4A / O75164 / lysine demethylase 4A  / complex / reaction
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex
 ENSG00000204371 EHMT2 / Q96KQ7 / euchromatic histone lysine methyltransferase 2  / reaction
 ENSG00000126457 PRMT1 / Q99873 / protein arginine methyltransferase 1  / reaction
 ENSG00000107077 KDM4C / Q9H3R0 / lysine demethylase 4C  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000079246 XRCC5 / P13010 / X-ray repair cross complementing 5  / reaction
 ENSG00000087206 UIMC1 / Q96RL1 / ubiquitin interaction motif containing 1  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex
 ENSG00000276043 UHRF1 / Q96T88 / ubiquitin like with PHD and ring finger domains 1  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction
 ENSG00000180573 Q93077 / HIST1H2AC / histone cluster 1 H2A family member c  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000119772 DNMT3A / Q9Y6K1 / DNA methyltransferase 3 alpha  / complex / reaction
 ENSG00000159055 MIS18A / Q9NYP9 / MIS18 kinetochore protein A  / complex
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction / complex
 ENSG00000122565 CBX3 / Q13185 / chromobox 3  / reaction / complex
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / reaction / complex
 ENSG00000134046 MBD2 / Q9UBB5 / methyl-CpG binding domain protein 2  / reaction / complex
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / complex / reaction
 ENSG00000142182 DNMT3L / Q9UJW3 / DNA methyltransferase 3 like  / complex / reaction
 ENSG00000100811 YY1 / P25490 / YY1 transcription factor  / complex
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction / complex
 ENSG00000088305 DNMT3B / Q9UBC3 / DNA methyltransferase 3 beta  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000104147 OIP5 / O43482 / Opa interacting protein 5  / complex
 ENSG00000092847 AGO1 / Q9UL18 / argonaute 1, RISC catalytic component  / complex / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction / complex
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / complex / reaction
 ENSG00000157212 PAXIP1 / Q6ZW49 / PAX interacting protein 1  / reaction / complex
 ENSG00000077463 SIRT6 / Q8N6T7 / sirtuin 6  / complex / reaction
 ENSG00000129534 Q6P0N0 / MIS18BP1 / MIS18 binding protein 1  / complex
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / reaction / complex
 ENSG00000118058 KMT2A / Q03164 / lysine methyltransferase 2A  / complex / reaction
 ENSG00000132275 RRP8 / O43159 / ribosomal RNA processing 8  / complex / reaction
 ENSG00000115163 CENPA / P49450 / centromere protein A  / complex






 

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