ENSG00000136997


Homo sapiens

Features
Gene ID: ENSG00000136997
  
Biological name :MYC
  
Synonyms : MYC / MYC proto-oncogene, bHLH transcription factor / P01106
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.21
Gene start: 127735434
Gene end: 127741434
  
Corresponding Affymetrix probe sets: 202431_s_at (Human Genome U133 Plus 2.0 Array)   239931_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429441
Ensembl peptide - ENSP00000430226
Ensembl peptide - ENSP00000493145
Ensembl peptide - ENSP00000493139
Ensembl peptide - ENSP00000479618
Ensembl peptide - ENSP00000478887
Ensembl peptide - ENSP00000430235
Ensembl peptide - ENSP00000259523
Ensembl peptide - ENSP00000367207
NCBI entrez gene - 4609     See in Manteia.
OMIM - 190080
RefSeq - NM_002467
RefSeq Peptide - NP_002458
swissprot - A0A087WVR4
swissprot - A0A087WUS5
swissprot - A0A024R9L7
swissprot - H0YBG3
swissprot - H0YBT0
swissprot - P01106
swissprot - Q14899
swissprot - E5RGD7
swissprot - Q16591
swissprot - A0A0B4J1R1
Ensembl - ENSG00000136997
  
Related genetic diseases (OMIM): 113970 - Burkitt lymphoma, 113970

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mycaENSDARG00000045695Danio rerio
 mycbENSDARG00000007241Danio rerio
 MYCENSGALG00000033631Gallus gallus
 MycENSMUSG00000022346Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYCN / P04198 / MYCN proto-oncogene, bHLH transcription factorENSG0000013432337
MYCL / P12524 / MYCL proto-oncogene, bHLH transcription factorENSG0000011699023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002418  Transcription regulator Myc
 IPR003327  Leucine zipper, Myc
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR012682  Transcription regulator Myc, N-terminal
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000320 re-entry into mitotic cell cycle IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation ISS
 biological_processGO:0002082 regulation of oxidative phosphorylation IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006112 energy reserve metabolic process NAS
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006848 pyruvate transport IEA
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007007 inner mitochondrial membrane organization IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009812 flavonoid metabolic process IEA
 biological_processGO:0010332 response to gamma radiation IDA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0015671 oxygen transport NAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0019087 transformation of host cell by virus IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0032204 regulation of telomere maintenance IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade ISS
 biological_processGO:0032986 protein-DNA complex disassembly IDA
 biological_processGO:0034644 cellular response to UV IEP
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044346 fibroblast apoptotic process TAS
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0045023 G0 to G1 transition IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IMP
 biological_processGO:0045727 positive regulation of translation NAS
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046722 lactic acid secretion IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0051276 chromosome organization IDA
 biological_processGO:0051782 negative regulation of cell division IDA
 biological_processGO:0051973 positive regulation of telomerase activity ISS
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070848 response to growth factor TAS
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071322 cellular response to carbohydrate stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071378 cellular response to growth hormone stimulus IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IEA
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0071464 cellular response to hydrostatic pressure IEA
 biological_processGO:0071966 fungal-type cell wall polysaccharide metabolic process IEA
 biological_processGO:0090096 positive regulation of metanephric cap mesenchymal cell proliferation ISS
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901857 positive regulation of cellular respiration IEA
 biological_processGO:1903841 cellular response to arsenite(3-) IEA
 biological_processGO:1903862 positive regulation of oxidative phosphorylation IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:1904586 cellular response to putrescine IEA
 biological_processGO:1904620 cellular response to dimethyl sulfoxide IEA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IEA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 biological_processGO:1990646 cellular response to prolactin IEA
 biological_processGO:1990858 cellular response to lectin IEA
 biological_processGO:1990859 cellular response to endothelin IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IMP
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IDA
 biological_processGO:2001171 positive regulation of ATP biosynthetic process IEA
 cellular_componentGO:0000790 nuclear chromatin IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0044195 nucleoplasmic reticulum IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0070888 E-box binding IDA
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding IPI


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
TFAP2 (AP-2) family regulates transcription of cell cycle factors
RUNX3 regulates WNT signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000137 Abnormality of the ovaries 
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 HP:0001392 Abnormality of the liver 
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 HP:0001732 Abnormality of the pancreas 
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 HP:0001743 Abnormality of the spleen 
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 HP:0002017 Nausea and vomiting 
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 HP:0002027 Abdominal pain 
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 HP:0002149 Hyperuricemia "An abnormally high level of uric acid in the blood." [HPO:curators]
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 HP:0002239 Gastrointestinal hemorrhage 
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 HP:0002733 Abnormality of the lymph nodes 
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 HP:0003745 Sporadic 
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 HP:0005214 Intestinal obstruction 
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 HP:0005407 Decreased number of CD4+ T cells 
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 HP:0005561 Generalized abnormality of the bone marrow 
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 HP:0030080 Burkitt lymphoma "A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass." []
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 HP:0045040 Abnormal lactate dehydrogenase activity 
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 HP:0100649 Neoplasia of the oral cavity 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000048028 USP28 / Q96RU2 / ubiquitin specific peptidase 28  / complex
 ENSG00000087510 Q92754 / TFAP2C / transcription factor AP-2 gamma  / reaction / complex
 ENSG00000125952 MAX / P61244 / MYC associated factor X  / complex
 ENSG00000117139 KDM5B / Q9UGL1 / lysine demethylase 5B  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000180573 Q93077 / HIST1H2AC / histone cluster 1 H2A family member c  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction






 

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