ENSG00000087510


Homo sapiens

Features
Gene ID: ENSG00000087510
  
Biological name :TFAP2C
  
Synonyms : Q92754 / TFAP2C / transcription factor AP-2 gamma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.31
Gene start: 56629302
Gene end: 56639283
  
Corresponding Affymetrix probe sets: 205286_at (Human Genome U133 Plus 2.0 Array)   205287_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000201031
Ensembl peptide - ENSP00000390857
NCBI entrez gene - 7022     See in Manteia.
OMIM - 601602
RefSeq - NM_003222
RefSeq Peptide - NP_003213
swissprot - A2A2R7
swissprot - Q92754
Ensembl - ENSG00000087510
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2cENSDARG00000040606Danio rerio
 TFAP2CENSGALG00000007690Gallus gallus
 Q61312ENSMUSG00000028640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P05549 / TFAP2A / transcription factor AP-2 alphaENSG0000013720359
Q92481 / TFAP2B / transcription factor AP-2 betaENSG0000000819658
Q6VUC0 / TFAP2E / transcription factor AP-2 epsilonENSG0000011681951
Q7Z6R9 / TFAP2D / transcription factor AP-2 deltaENSG0000000819744


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008123  Transcription factor AP-2 gamma
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008584 male gonad development IEP
 biological_processGO:0040029 regulation of gene expression, epigenetic IMP
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IDA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
TFAP2 (AP-2) family regulates transcription of other transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008196 Q92481 / TFAP2B / transcription factor AP-2 beta  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000137203 P05549 / TFAP2A / transcription factor AP-2 alpha  / reaction / complex
 ENSG00000153885 KCTD15 / Q96SI1 / potassium channel tetramerization domain containing 15  / reaction / complex
 ENSG00000136997 MYC / P01106 / MYC proto-oncogene, bHLH transcription factor  / complex / reaction
 ENSG00000087510 Q92754 / TFAP2C / transcription factor AP-2 gamma  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000134504 KCTD1 / Q719H9 / potassium channel tetramerization domain containing 1  / complex / reaction
 ENSG00000186153 WWOX / Q9NZC7 / WW domain containing oxidoreductase  / complex / reaction
 ENSG00000117139 KDM5B / Q9UGL1 / lysine demethylase 5B  / reaction / complex
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction / complex
 ENSG00000164442 CITED2 / Q99967 / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2  / complex / reaction
 ENSG00000179862 CITED4 / Q96RK1 / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4  / complex / reaction






 

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