ENSMUSG00000028640


Mus musculus

Features
Gene ID: ENSMUSG00000028640
  
Biological name :Tfap2c
  
Synonyms : Q61312 / Tfap2c / transcription factor AP-2, gamma
  
Possible biological names infered from orthology : Q92754
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 172549593
Gene end: 172558622
  
Corresponding Affymetrix probe sets: 10478997 (MoGene1.0st)   1418147_at (Mouse Genome 430 2.0 Array)   1436392_s_at (Mouse Genome 430 2.0 Array)   1448977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129922
Ensembl peptide - ENSMUSP00000030391
Ensembl peptide - ENSMUSP00000096657
NCBI entrez gene - 21420     See in Manteia.
MGI - MGI:106032
RefSeq - XM_017316957
RefSeq - NM_001159696
RefSeq - NM_009335
RefSeq - XM_006499102
RefSeq - XM_006499103
RefSeq Peptide - NP_033361
RefSeq Peptide - NP_001153168
swissprot - Q3ULB3
swissprot - A2APA8
swissprot - Q61312
swissprot - A0A023UF19
Ensembl - ENSMUSG00000028640
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2cENSDARG00000040606Danio rerio
 TFAP2CENSGALG00000007690Gallus gallus
 Q92754ENSG00000087510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tfap2a / transcription factor AP-2, alpha / P05549*ENSMUSG0000002135953
Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*ENSMUSG0000002592751
Q6VUP9 / Tfap2e / transcription factor AP-2, epsilon / Q6VUC0*ENSMUSG0000004247748
Q91ZK0 / Tfap2d / transcription factor AP-2, delta / Q7Z6R9*ENSMUSG0000004259640


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008123  Transcription factor AP-2 gamma
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0001942 hair follicle development IGI
 biological_processGO:0003334 keratinocyte development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0021877 forebrain neuron fate commitment IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043588 skin development IGI
 biological_processGO:0045682 regulation of epidermis development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048733 sebaceous gland development IGI
 biological_processGO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0001717 absent ectoplacental cone 
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pthlhtm1Ack/Pthlhtm1Hmk,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpertm1Cpat/Bmper+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0002584 small ectoplacental cone 
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011207 absent ectoplacental cavity "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
Show

Allelic Composition: Tfap2ctm1Will/Tfap2ctm1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004637 Wwox / Q91WL8 / WW domain-containing oxidoreductase / Q9NZC7*  / reaction / complex
 ENSMUSG00000025927 Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*  / complex / reaction
 ENSMUSG00000036225 Kctd1 / Q5M956 / BTB/POZ domain-containing protein KCTD1 / Q719H9* / potassium channel tetramerization domain containing 1*  / complex / reaction
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000042207 Kdm5b / Q80Y84 / Lysine-specific demethylase 5B / Q9UGL1* / lysine demethylase 5B*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000022346 Myc / P01108 / myelocytomatosis oncogene / P01106* / MYC proto-oncogene, bHLH transcription factor*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000039910 Cited2 / O35740 / Cbp/p300-interacting transactivator 2 / Q99967* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2*  / complex / reaction
 ENSMUSG00000070803 Cited4 / Q9WUL8 / Cbp/p300-interacting transactivator 4 / Q96RK1* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4*  / complex / reaction






 

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