ENSMUSG00000042477


Mus musculus

Features
Gene ID: ENSMUSG00000042477
  
Biological name :Tfap2e
  
Synonyms : Q6VUP9 / Tfap2e / transcription factor AP-2, epsilon
  
Possible biological names infered from orthology : Q6VUC0
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 126716006
Gene end: 126736240
  
Corresponding Affymetrix probe sets: 10516419 (MoGene1.0st)   1435205_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035902
NCBI entrez gene - 332937     See in Manteia.
MGI - MGI:2679630
RefSeq - NM_198960
RefSeq Peptide - NP_945198
swissprot - Q6VUP9
Ensembl - ENSMUSG00000042477
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2eENSDARG00000008861Danio rerio
 TFAP2EENSGALG00000039497Gallus gallus
 Q6VUC0ENSG00000116819Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*ENSMUSG0000002592761
Tfap2a / transcription factor AP-2, alpha / P05549*ENSMUSG0000002135960
Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*ENSMUSG0000002864052
Q91ZK0 / Tfap2d / transcription factor AP-2, delta / Q7Z6R9*ENSMUSG0000004259648


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048856 anatomical structure development IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Skn/Sox2tm4.1Skn,Tg(Nes-cre)1Kln/0
Genetic Background: either: (involves: 129S/Sv * C57BL/6 * SJL) or (involves: 129S/Sv * C57BL/6 * DBA/2 * SJL)

Allelic Composition: Tfap2etm1(cre)Will/Tfap2etm1(cre)Will
Genetic Background: involves: 129S1/Sv * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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