ENSMUSG00000025927


Mus musculus

Features
Gene ID: ENSMUSG00000025927
  
Biological name :Tfap2b
  
Synonyms : Q61313 / Tfap2b / transcription factor AP-2 beta
  
Possible biological names infered from orthology : Q92481
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A3
Gene start: 19208914
Gene end: 19238576
  
Corresponding Affymetrix probe sets: 10345016 (MoGene1.0st)   1423340_at (Mouse Genome 430 2.0 Array)   1435670_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027059
Ensembl peptide - ENSMUSP00000064488
Ensembl peptide - ENSMUSP00000140213
NCBI entrez gene - 21419     See in Manteia.
MGI - MGI:104672
RefSeq - XM_006495495
RefSeq - NM_001025305
RefSeq - NM_001286340
RefSeq - NM_009334
RefSeq - XM_006495491
RefSeq - XM_006495492
RefSeq - XM_006495493
RefSeq - XM_006495494
RefSeq Peptide - NP_001020476
RefSeq Peptide - NP_001273269
RefSeq Peptide - NP_033360
swissprot - Q8CE69
swissprot - E9Q5N4
swissprot - Q61313
Ensembl - ENSMUSG00000025927
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2bENSDARG00000012667Danio rerio
 TFAP2BENSGALG00000016680Gallus gallus
 Q92481ENSG00000008196Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tfap2a / transcription factor AP-2, alpha / P05549*ENSMUSG0000002135966
Q6VUP9 / Tfap2e / transcription factor AP-2, epsilon / Q6VUC0*ENSMUSG0000004247759
Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*ENSMUSG0000002864054
Q91ZK0 / Tfap2d / transcription factor AP-2, delta / Q7Z6R9*ENSMUSG0000004259647


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008122  Transcription factor AP-2 beta
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003091 renal water homeostasis IMP
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007423 sensory organ development IEP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0010960 magnesium ion homeostasis IMP
 biological_processGO:0030510 regulation of BMP signaling pathway IMP
 biological_processGO:0035136 forelimb morphogenesis IMP
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0035810 positive regulation of urine volume IMP
 biological_processGO:0035909 aorta morphogenesis IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043588 skin development IEP
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048485 sympathetic nervous system development IGI
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0055062 phosphate ion homeostasis IMP
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0055075 potassium ion homeostasis IMP
 biological_processGO:0055078 sodium ion homeostasis IMP
 biological_processGO:0072017 distal tubule development IMP
 biological_processGO:0072044 collecting duct development IMP
 biological_processGO:0072210 metanephric nephron development IEP
 biological_processGO:0097070 ductus arteriosus closure IMP
 biological_processGO:0097275 cellular ammonia homeostasis IMP
 biological_processGO:0097276 cellular creatinine homeostasis IMP
 biological_processGO:0097277 cellular urea homeostasis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001059 optic nerve atrophy "wasting of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tfap2btm1Rbu/Tfap2b+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

Allelic Composition: Tfap2btm1Rbu/Tfap2btm1Rbu
Genetic Background: 129P2.129-Tfap2btm1Rbu

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004283 absent corneal endothelium "absence of the single layer of large flattened cells that cover the surface of the cornea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005099 abnormal ciliary body morphology "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005497 optic nerve cupping "concave shape of the nerve often as a result of the force of pressure from glaucoma" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006219 optic nerve degeneration "retrogressive pathologic change of the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008067 retinal ganglion cell degeneration "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm1Rbu
Genetic Background: 129P2.129-Tfap2btm1Rbu

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Tfap2btm1Rbu/Tfap2b+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010252 anterior subcapsular cataracts "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm1Rbu
Genetic Background: 129P2.129-Tfap2btm1Rbu

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: PhexHyp/Phex+
Genetic Background: C57BL/6J

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Tfap2btm1Rbu/Tfap2btm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020171 Q9CR11 / Yeats4 / YEATS domain containing 4 / O95619*  / complex / reaction
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000025927 Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*  / reaction / complex
 ENSMUSG00000036225 Kctd1 / Q5M956 / BTB/POZ domain-containing protein KCTD1 / Q719H9* / potassium channel tetramerization domain containing 1*  / reaction / complex
 ENSMUSG00000039910 Cited2 / O35740 / Cbp/p300-interacting transactivator 2 / Q99967* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2*  / complex / reaction
 ENSMUSG00000070803 Cited4 / Q9WUL8 / Cbp/p300-interacting transactivator 4 / Q96RK1* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4*  / reaction / complex






 

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