ENSMUSG00000039910


Mus musculus

Features
Gene ID: ENSMUSG00000039910
  
Biological name :Cited2
  
Synonyms : Cbp/p300-interacting transactivator 2 / Cited2 / O35740
  
Possible biological names infered from orthology : Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 / Q99967
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A2
Gene start: 17723218
Gene end: 17725674
  
Corresponding Affymetrix probe sets: 10361828 (MoGene1.0st)   1421267_a_at (Mouse Genome 430 2.0 Array)   1452207_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151452
Ensembl peptide - ENSMUSP00000151600
Ensembl peptide - ENSMUSP00000038405
NCBI entrez gene - 17684     See in Manteia.
MGI - MGI:1306784
RefSeq - NM_010828
RefSeq Peptide - NP_034958
swissprot - A0A1W2P7B1
swissprot - O35740
Ensembl - ENSMUSG00000039910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cited2ENSDARG00000030905Danio rerio
 CITED2ENSGALG00000013818Gallus gallus
 CITED2ENSG00000164442Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cited1 / P97769 / Cbp/p300-interacting transactivator 1 / Q99966* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1*ENSMUSG0000005115923
Cited4 / Q9WUL8 / Cbp/p300-interacting transactivator 4 / Q96RK1* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4*ENSMUSG0000007080319


Protein motifs (from Interpro)
Interpro ID Name
 IPR007576  CITED


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002521 leukocyte differentiation IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003156 regulation of animal organ formation IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007530 sex determination IMP
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0022409 positive regulation of cell-cell adhesion IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0030336 negative regulation of cell migration ISO
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030851 granulocyte differentiation IMP
 biological_processGO:0034405 response to fluid shear stress ISO
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
 biological_processGO:0035802 adrenal cortex formation IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046697 decidualization IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060136 embryonic process involved in female pregnancy IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0060411 cardiac septum morphogenesis IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060971 embryonic heart tube left/right pattern formation IMP
 biological_processGO:0061156 pulmonary artery morphogenesis IMP
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
 biological_processGO:0070986 left/right axis specification IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IMP
 biological_processGO:2000020 positive regulation of male gonad development IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0035035 histone acetyltransferase binding ISO
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0050693 LBD domain binding ISO


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Activation of the TFAP2 (AP-2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ikzf1tm1Kast/Ikzf1tm1Kast
Genetic Background: involves: 129S2/SvPas

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000486 abnormal pulmonary trunk morphology "structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000508 right-sided isomerism "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the right atrium" [J:58530, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Jpmb/Cited2tm1Jpmb
Genetic Background: involves: 129P2/OlaHsd

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: B6.Cg-Cited2tm1Ycy

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0000650 mesocardia "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1.2Dunw/Cited2tm1.2Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1.2Dunw/Cited2tm1.2Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1.1Dunw/Cited2tm1.1Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ybx1tm1Ley/Ybx1tm1Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cited2tm1.1Dunw/Cited2tm1.1Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cited2tm3.1Bha/Cited2tm3.1Bha
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm3.1Bha
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm4Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Cited2tm5Bha/Cited2tm5Bha
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Cited2tm1Bha/Cited2tm5Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Cited2tm6Bha/Cited2tm6Bha
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Cited2tm1Bha/Cited2tm6Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Allelic Composition: Cited2m1Bha/Cited2m1Bha
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1.1Dunw/Cited2tm1.1Dunw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: B6.Cg-Cited2tm1Ycy

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005313 absent adrenal gland "missing endocrine glands that are normally located above the kidney and responsible for hormone and epinepherine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56651]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: B6.Cg-Cited2tm1Ycy

 MP:0006046 atrioventricular valve insufficiency "the atrioventricular valves do not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0006065 abnormal heart position "the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0009688 abnormal spinal cord central canal morphology "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0010029 abnormal basicranium morphology "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010406 absent atrial septum "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129 * C3H * C57BL/6 * SJL

 MP:0010426 abnormal heart and great artery attachment "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0010437 absent coronary sinus "absence of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0010465 aberrant origin of the right subclavian artery "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0010714 coloboma of the iris "congenital defect of the iris in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0010807 abnormal stomach position or orientation "the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010814 absent alveolar lamellar bodies "absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: B6.Cg-Cited2tm1Ycy

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: B6.Cg-Cited2tm1Ycy

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Jpmb/Cited2tm1Jpmb
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cited2tm1Ycy/Cited2tm1Ycy
Genetic Background: involves: C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Ycy/Cited2+
Genetic Background: involves: C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm2Bha,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012747 abnormal cardiac neural crest cell morphology "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
Show

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012749 decreased cardiac neural crest cell number "reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012750 absent cardiac neural crest cells "absence or loss of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia; ablation of cardiac NCCs results in cardiac outflow defects" [MGI:anna]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013176 abnormal tail position or orientation " tail is displaced from the normal location and/or does not orient in a typical pattern" [MGI:anna]
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Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cited2tm1Bha/Cited2tm1Bha
Genetic Background: B6.129P2-Cited2tm1Bha

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028640 Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000025927 Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*  / complex / reaction






 

1 s.

 
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