ENSMUSG00000051159


Mus musculus

Features
Gene ID: ENSMUSG00000051159
  
Biological name :Cited1
  
Synonyms : Cbp/p300-interacting transactivator 1 / Cited1 / P97769
  
Possible biological names infered from orthology : Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 / Q99966
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 102247381
Gene end: 102252181
  
Corresponding Affymetrix probe sets: 10606083 (MoGene1.0st)   1449031_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098890
Ensembl peptide - ENSMUSP00000117702
Ensembl peptide - ENSMUSP00000119123
Ensembl peptide - ENSMUSP00000051789
Ensembl peptide - ENSMUSP00000114269
NCBI entrez gene - 12705     See in Manteia.
MGI - MGI:108023
RefSeq - NM_001276466
RefSeq - NM_001276473
RefSeq - NM_001276474
RefSeq - NM_007709
RefSeq Peptide - NP_031735
RefSeq Peptide - NP_001263395
RefSeq Peptide - NP_001263402
RefSeq Peptide - NP_001263403
swissprot - F6YUL1
swissprot - A0A0A0MQI7
swissprot - P97769
swissprot - Q3UGA1
swissprot - F6ZC52
Ensembl - ENSMUSG00000051159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cited1ENSDARG00000077769Danio rerio
 CITED1ENSG00000125931Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cited2 / O35740 / Cbp/p300-interacting transactivator 2 / Q99967* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2*ENSMUSG0000003991031
Cited4 / Q9WUL8 / Cbp/p300-interacting transactivator 4 / Q96RK1* / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4*ENSMUSG0000007080322


Protein motifs (from Interpro)
Interpro ID Name
 IPR007576  CITED


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IEA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0034341 response to interferon-gamma IDA
 biological_processGO:0042438 melanin biosynthetic process IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051591 response to cAMP IDA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:0070669 response to interleukin-2 IDA
 biological_processGO:0070670 response to interleukin-4 IDA
 biological_processGO:0070741 response to interleukin-6 IDA
 biological_processGO:0071104 response to interleukin-9 IDA
 biological_processGO:0071105 response to interleukin-11 IDA
 biological_processGO:0071107 response to parathyroid hormone IDA
 biological_processGO:0071559 response to transforming growth factor beta IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0050693 LBD domain binding IEA
 molecular_functionGO:0070410 co-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Activation of the TFAP2 (AP-2) family of transcription factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1tm1Dunw
Genetic Background: B6.129P2-Cited1tm1Dunw

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cited2tm1Jpmb/Cited2tm1Jpmb
Genetic Background: involves: 129P2/OlaHsd

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0012098 increased spongiotrophoblast size "greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cited1tm1Dunw/Y
Genetic Background: B6.129P2-Cited1tm1Dunw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex






 

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