ENSG00000125931


Homo sapiens

Features
Gene ID: ENSG00000125931
  
Biological name :CITED1
  
Synonyms : Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 / CITED1 / Q99966
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q13.1
Gene start: 72301638
Gene end: 72307187
  
Corresponding Affymetrix probe sets: 207144_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401764
Ensembl peptide - ENSP00000403274
Ensembl peptide - ENSP00000414781
Ensembl peptide - ENSP00000412769
Ensembl peptide - ENSP00000407496
Ensembl peptide - ENSP00000405765
Ensembl peptide - ENSP00000246139
Ensembl peptide - ENSP00000362721
Ensembl peptide - ENSP00000388548
Ensembl peptide - ENSP00000391407
NCBI entrez gene - 4435     See in Manteia.
OMIM - 300149
RefSeq - XM_011530958
RefSeq - NM_001144885
RefSeq - NM_001144886
RefSeq - NM_001144887
RefSeq - NM_004143
RefSeq Peptide - NP_001138359
RefSeq Peptide - NP_004134
RefSeq Peptide - NP_001138357
RefSeq Peptide - NP_001138358
swissprot - C9J1P6
swissprot - H7C2S6
swissprot - C9J7P8
swissprot - C9J300
swissprot - Q99966
swissprot - C9JRD8
Ensembl - ENSG00000125931
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cited1ENSDARG00000077769Danio rerio
 Cited1ENSMUSG00000051159Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CITED2 / Q99967 / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2ENSG0000016444227
CITED4 / Q96RK1 / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4ENSG0000017986224


Protein motifs (from Interpro)
Interpro ID Name
 IPR007576  CITED


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000578 embryonic axis specification IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001656 metanephros development TAS
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0001890 placenta development ISS
 biological_processGO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006913 nucleocytoplasmic transport IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway TAS
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032868 response to insulin ISS
 biological_processGO:0034097 response to cytokine ISS
 biological_processGO:0034341 response to interferon-gamma ISS
 biological_processGO:0042438 melanin biosynthetic process ISS
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0043627 response to estrogen TAS
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051591 response to cAMP ISS
 biological_processGO:0060231 mesenchymal to epithelial transition TAS
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0060711 labyrinthine layer development IEA
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 biological_processGO:0070555 response to interleukin-1 ISS
 biological_processGO:0070669 response to interleukin-2 ISS
 biological_processGO:0070670 response to interleukin-4 ISS
 biological_processGO:0070741 response to interleukin-6 ISS
 biological_processGO:0071104 response to interleukin-9 ISS
 biological_processGO:0071105 response to interleukin-11 ISS
 biological_processGO:0071107 response to parathyroid hormone ISS
 biological_processGO:0071559 response to transforming growth factor beta IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0050693 LBD domain binding IDA
 molecular_functionGO:0070410 co-SMAD binding IPI


Pathways (from Reactome)
Pathway description
Activation of the TFAP2 (AP-2) family of transcription factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction






 

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