ENSMUSG00000021359


Mus musculus

Features
Gene ID: ENSMUSG00000021359
  
Biological name :Tfap2a
  
Synonyms : Tfap2a / transcription factor AP-2, alpha
  
Possible biological names infered from orthology : P05549
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 40715302
Gene end: 40738376
  
Corresponding Affymetrix probe sets: 10408798 (MoGene1.0st)   1421995_at (Mouse Genome 430 2.0 Array)   1421996_at (Mouse Genome 430 2.0 Array)   1426048_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153522
Ensembl peptide - ENSMUSP00000105822
Ensembl peptide - ENSMUSP00000153667
Ensembl peptide - ENSMUSP00000153149
Ensembl peptide - ENSMUSP00000153271
Ensembl peptide - ENSMUSP00000021787
NCBI entrez gene - 21418     See in Manteia.
MGI - MGI:104671
RefSeq - NM_011547
RefSeq - XM_017315479
RefSeq - XM_006516903
RefSeq - XM_006516902
RefSeq - NM_001122948
RefSeq - NM_001301674
RefSeq Peptide - NP_001116420
RefSeq Peptide - NP_001288603
RefSeq Peptide - NP_035677
swissprot - A0A286YD43
swissprot - Q8BPN4
swissprot - A0A0R4J1E6
swissprot - A0A286YDR3
swissprot - A0A286YCU0
Ensembl - ENSMUSG00000021359
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2aENSDARG00000059279Danio rerio
 TFAP2AENSGALG00000012775Gallus gallus
 P05549ENSG00000137203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61313 / Tfap2b / transcription factor AP-2 beta / Q92481*ENSMUSG0000002592770
Q6VUP9 / Tfap2e / transcription factor AP-2, epsilon / Q6VUC0*ENSMUSG0000004247760
Q61312 / Tfap2c / transcription factor AP-2, gamma / Q92754*ENSMUSG0000002864059
Q91ZK0 / Tfap2d / transcription factor AP-2, delta / Q7Z6R9*ENSMUSG0000004259650


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008121  Transcription factor AP-2 alpha, N-terminal
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0070172 positive regulation of tooth mineralization IEA
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0000039 abnormal otic capsule morphology "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000040 absent middle ear ossicles "missing small bones of the tympanic cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0000158 absent sternum "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srcinl/Srcinl
Genetic Background: involves: 129

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0000450 absent snout "missing anterior facial part of the muzzle" [J:35802]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000453 absent mouth "missing oral cavity" [J:35802]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000553 absent radius "missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Hoxb1tm5Mrc/Hoxb1tm7Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001062 absent oculomotor nerve "missing nerve of the extraocular muscles, iris and ciliary body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Pygo2tm1.1Ssp/Pygo2tm1.2Ssp,Tfap2atm1(cre)Moon/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Pygo2tm1.1Ssp/Pygo2tm1.2Ssp,Tfap2atm1(cre)Moon/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
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Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2atm2Will/Tfap2a+,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Tfap2atm2.1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002820 abnormal premaxilla morphology "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0003388 absent pericardium "absence of the fibroserous membrane covering the heart and beginning of the great vessels" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003395 abnormal subclavian artery morphology "malformation of the right or left subclavian arteries, The right subclavian artery extends from the brachiocephalic artery to the right side of the body. The left subclavian artery extends from the aortic arch to the left side of the body." [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004339 absent clavicle "missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0004379 wide frontal bone "increased width of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0004380 short frontal bone "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0004419 absent parietal bone "absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0004468 small zygomatic bone "reduced size of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0004472 broad nasal bone "increased width of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0004673 splayed ribs "any deviation from the normal curvature of the ribs such that the ribs are turned outward " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0004739 conductive hearing loss "progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

Allelic Composition: Tfap2atm1Jae/Tfap2a+
Genetic Background: involves: 129P/Ola * 129S4/SvJae

 MP:0005106 abnormal incus morphology "structural anomaly of the middle of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0005107 abnormal stapes morphology "structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0005174 abnormal tail pigmentation "anomalous color of the tail in relation to control animals" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005261 aniridia "abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006128 pulmonary valve stenosis "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0006130 pulmonary valve atresia "congenital closure of the pulmonary valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0006211 small orbits "reduced size of the orbits" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0006306 abnormal nasal pit morphology "malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2aMhdador/Tfap2a+
Genetic Background: involves: C3HeB/FeJ

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0008510 absent retinal ganglion layer "absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009379 abnormal foot pigmentation "anomaly in the coloration of the foot" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0009844 abnormal neural crest cell apoptosis "change in the timing or the number of neural crest cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0009893 cleft primary palate "congenital fissure of the tissues normally uniting to form the primary palate" [PMID:16680722]
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Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss

 MP:0009902 abnormal lateral nasal prominence morphology "any structural anomaly of the lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0009903 abnormal medial nasal prominence morphology "any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010043 abnormal frontonasal suture morphology "any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0010241 abnormal aortic arch development "anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010465 aberrant origin of the right subclavian artery "the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm2.1Bem,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0010572 persistent right dorsal aorta "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss

Allelic Composition: Tfap2atm1.1Hsv/Tfap2atm1.1Hsv
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

 MP:0010940 abnormal maxillary prominence morphology 
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Tfap2atm1Jae/Tfap2atm1Jae
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c)

Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,Tfap2ctm1Will/Tfap2ctm2Will,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012747 abnormal cardiac neural crest cell morphology "any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Meis2tm1.1Zkoz/Meis2tm1.1Zkoz,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129 * C57BL/6J

 MP:0013550 abnormal secondary palate morphology 
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Allelic Composition: Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
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Allelic Composition: Fgf8tm1.4Mrt/Fgf8+,Tfap2atm1Will/Tfap2atm2.1Will
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss

 MP:0030191 narrow snout "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Tfap2aMhdador/Tfap2aMhdador
Genetic Background: involves: C3HeB/FeJ

 MP:0030200 abnormal nasal septum cartilage morphology "any structural anomaly of the hyaline cartilage of the nasal septum that is somewhat quadrilateral in shape, thicker at its margins than at its center, and completes the separation between the nasal cavities" [https://en.wikipedia.org/wiki/Septal_nasal_cartilage, MGI:anna]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0030334 absent sixth pharyngeal arch artery "failure to develop or absence of the sixth pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030337 enlarged third pharyngeal arch artery "increased size of the third pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030340 absent fourth pharyngeal arch artery "failure to develop or absence of the fourth pharyngeal arch artery" [MGI:anna]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030341 fourth pharyngeal arch artery hypoplasia "underdevelopment or reduced size of the fourth pharyngeal arch artery, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Mrc,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fgf8tm1Mrc/Fgf8tm1Moon,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tbx1tm2.1Bem/Tbx1+,Tfap2atm1(cre)Moon/Tfap2a+
Genetic Background: either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

 MP:0030531 abnormal facial skin morphology "any anomaly in a zone of skin that is part of the face" [UBERON:1000021]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0030532 abnormal periorbital skin morphology "any anomaly in a zone of skin that is part of the periorbital region of the face" [UBERON:0016462]
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Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0030579 thoracoabdominoschisis "a congenital fissure of both the thoracic and abdominal walls" [https://www.ncbi.nlm.nih.gov/medgen/672583]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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