ENSGALG00000012775


Gallus gallus

Features
Gene ID: ENSGALG00000012775
  
Biological name :TFAP2A
  
Synonyms : TFAP2A / transcription factor AP-2-alpha
  
Possible biological names infered from orthology : P05549
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 63495555
Gene end: 63509044
  
Corresponding Affymetrix probe sets: Gga.2351.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020815
NCBI entrez gene - 395982     See in Manteia.
RefSeq - XM_015275848
RefSeq - NM_205094
RefSeq - XM_015275846
RefSeq - XM_015275847
RefSeq - XM_015275844
RefSeq - XM_015275845
RefSeq Peptide - NP_990425
swissprot - F1P4X0
Ensembl - ENSGALG00000012775
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tfap2aENSDARG00000059279Danio rerio
 P05549ENSG00000137203Homo sapiens
 Tfap2aENSMUSG00000021359Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TFAP2B / transcription factor AP-2-beta / Q61313* / Q92481*ENSGALG0000001668069
TFAP2C / transcription factor AP-2 gamma / Q61312* / Q92754*ENSGALG0000000769066
TFAP2E / transcription factor AP-2 epsilon / Q6VUC0* / Q6VUP9*ENSGALG0000003949764
TFAP2D / transcription factor AP-2-delta / Q7Z6R9* / Q91ZK0*ENSGALG0000001984249


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008121  Transcription factor AP-2 alpha, N-terminal
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0070172 positive regulation of tooth mineralization IEA
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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