ENSDARG00000059279


Danio rerio

Features
Gene ID: ENSDARG00000059279
  
Biological name :tfap2a
  
Synonyms : tfap2a / transcription factor AP-2 alpha
  
Possible biological names infered from orthology : P05549
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 8721676
Gene end: 8732519
  
Corresponding Affymetrix probe sets: Dr.8506.1.S1_a_at (Zebrafish Array)   NM_176859_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000076787
Ensembl peptide - ENSDARP00000076782
Ensembl peptide - ENSDARP00000076785
Ensembl peptide - ENSDARP00000157668
Ensembl peptide - ENSDARP00000148170
Ensembl peptide - ENSDARP00000151904
NCBI entrez gene - 140618     See in Manteia.
RefSeq - NM_001319158
RefSeq - NM_001319159
RefSeq - NM_176859
RefSeq Peptide - NP_001306088
RefSeq Peptide - NP_789829
RefSeq Peptide - NP_001306087
swissprot - F1QUT4
swissprot - Q6P975
swissprot - Q6NYI3
swissprot - F1QUT5
ZFIN ID - ZDB-GENE-011212-6
Ensembl - ENSDARG00000059279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFAP2AENSGALG00000012775Gallus gallus
 P05549ENSG00000137203Homo sapiens
 Tfap2aENSMUSG00000021359Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tfap2b / transcription factor AP-2 beta / Q92481*ENSDARG0000001266764
tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*ENSDARG0000004060663
tfap2e / transcription factor AP-2 epsilon / Q6VUC0* / Q6VUP9*ENSDARG0000000886157
Q5RJ20 / tfap2d / transcription factor AP-2 delta (activating enhancer binding protein 2 delta) / Q7Z6R9* / transcription factor AP-2 delta*ENSDARG0000002327246


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR008121  Transcription factor AP-2 alpha, N-terminal
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0014032 neural crest cell development IGI
 biological_processGO:0014036 neural crest cell fate specification IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030318 melanocyte differentiation IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043049 otic placode formation IGI
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0050935 iridophore differentiation IMP
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060788 ectodermal placode formation IGI
 biological_processGO:0071599 otic vesicle development IMP
 biological_processGO:0071696 ectodermal placode development IGI
 biological_processGO:0071698 olfactory placode development IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
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 ZFA:0000029 hindbrain hindbrain quality , abnormal
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 ZFA:0000051 otic vesicle otic vesicle has fewer parts of type otic vesicle neuroblast (sensu Vertebrata), abnormal
otic vesicle neuroblast fate specification decreased occurrence , abnormal
otic vesicle neurogenesis decreased occurrence , abnormal
otic vesicle Notch signaling pathway increased process quality , abnormal
otic vesicle fibroblast growth factor receptor signaling pathway increased process quality , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton has fewer parts of type ceratobranchial cartilage , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
pharyngeal arch 3-7 skeleton decreased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000142 peripheral nervous system peripheral nervous system neuron distributed , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium mislocalised , abnormal
retinal pigmented epithelium protruding , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion neuron decreased amount , abnormal
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 ZFA:0000354 gill gill decreased size , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000539 locus coeruleus locus coeruleus adrenergic neuron absent , abnormal
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 ZFA:0000545 medulla oblongata medulla oblongata adrenergic neuron absent , abnormal
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 ZFA:0000547 mouth mouth quality , abnormal
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 ZFA:0000588 statoacoustic (VIII) ganglion statoacoustic (VIII) ganglion has fewer parts of type statoacoustic (VIII) ganglion neuron, abnormal
statoacoustic (VIII) ganglion neuron differentiation decreased rate , abnormal
statoacoustic (VIII) ganglion has extra parts of type statoacoustic (VIII) ganglion neuroblast (sensu Vertebrata), abnormal
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 ZFA:0000621 quadrate quadrate decreased length , abnormal
quadrate decreased size , abnormal
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 ZFA:0001058 caudal fin caudal fin ventral region decreased pigmentation , abnormal
caudal fin melanocyte decreased amount , abnormal
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 ZFA:0001078 thymus thymus decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism lacks all parts of type sympathetic nervous system neuron, abnormal
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 ZFA:0001115 trunk trunk decreased amount , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system neuron decreased amount , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
Meckels cartilage decreased size , abnormal
Meckels cartilage fused with Meckels cartilage , abnormal
Meckels cartilage sloped downward , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
mandibular arch skeleton disorganized , abnormal
mandibular arch skeleton protruding , abnormal
mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton mislocalised ventrally , abnormal
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 ZFA:0001228 pharyngeal arch 3 skeleton pharyngeal arch 3 skeleton decreased size , abnormal
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 ZFA:0001229 pharyngeal arch 7 skeleton pharyngeal arch 7 skeleton decreased size , abnormal
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 ZFA:0001230 pharyngeal arch 6 skeleton pharyngeal arch 6 skeleton absent , abnormal
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 ZFA:0001231 pharyngeal arch 4 skeleton pharyngeal arch 4 skeleton absent , abnormal
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 ZFA:0001232 pharyngeal arch 5 skeleton pharyngeal arch 5 skeleton absent , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton morphology , abnormal
pharyngeal arch 2 skeleton decreased size , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage disorganized , abnormal
palatoquadrate cartilage mislocalised , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
ceratohyal cartilage hypoplastic , abnormal
ceratohyal cartilage medially rotated , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage split , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased size , abnormal
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 ZFA:0001507 trabecula cranii trabecula cranii decreased length , abnormal
trabecula cranii decreased thickness , abnormal
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 ZFA:0001508 trabecula communis trabecula communis absent , abnormal
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 ZFA:0001510 basihyal cartilage basihyal cartilage decreased length , abnormal
basihyal cartilage decreased size , abnormal
basihyal cartilage mislocalised laterally , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased size , abnormal
ceratobranchial cartilage decreased amount , abnormal
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 ZFA:0001580 neurocranium neurocranium decreased size , abnormal
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 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 disorganized , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 decreased size , abnormal
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 ZFA:0005342 anterior catecholaminergic tract anterior catecholaminergic tract decreased size , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell decreased amount , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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 ZFA:0009090 pigment cell pigment cell decreased amount , abnormal
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 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte irregular spatial pattern , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000070108 dek / DEK proto-oncogene / P35659* / Q7TNV0* / Protein DEK *  / reaction / complex
 ENSDARG00000014329 npm1a / nucleophosmin 1a / NPM1* / Q61937* / P06748* / nucleophosmin 1*  / reaction / complex
 ENSDARG00000059279 tfap2a / transcription factor AP-2 alpha / P05549*  / complex / reaction
 ENSDARG00000074056 kctd1 / potassium channel tetramerization domain containing 1 / Q5M956* / Q719H9* / BTB/POZ domain-containing protein KCTD1 *  / complex / reaction
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / reaction / complex
 ENSDARG00000101009 cited4b / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b / Q9WUL8* / CITED4* / Q96RK1* / Cbp/p300-interacting transactivator 4 * / Cbp/p300 interacting t...  / complex / reaction






 

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