ENSDARG00000040606


Danio rerio

Features
Gene ID: ENSDARG00000040606
  
Biological name :tfap2c
  
Synonyms : tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
  
Possible biological names infered from orthology : Q61312 / Q92754 / transcription factor AP-2 gamma
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 56141852
Gene end: 56179707
  
Corresponding Affymetrix probe sets: Dr.11698.1.S1_at (Zebrafish Array)   Dr.11698.2.S1_at (Zebrafish Array)   NM_001008576_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123798
Ensembl peptide - ENSDARP00000124643
NCBI entrez gene - 494033     See in Manteia.
RefSeq - NM_001008576
RefSeq Peptide - NP_001008576
swissprot - F8W2Q6
swissprot - Q5PQZ4
ZFIN ID - ZDB-GENE-041212-61
Ensembl - ENSDARG00000040606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TFAP2CENSGALG00000007690Gallus gallus
 Q92754ENSG00000087510Homo sapiens
 Q61312ENSMUSG00000028640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tfap2a / transcription factor AP-2 alpha / P05549*ENSDARG0000005927963
tfap2b / transcription factor AP-2 beta / Q92481*ENSDARG0000001266758
tfap2e / transcription factor AP-2 epsilon / Q6VUC0* / Q6VUP9*ENSDARG0000000886154
Q5RJ20 / tfap2d / transcription factor AP-2 delta (activating enhancer binding protein 2 delta) / Q7Z6R9* / transcription factor AP-2 delta*ENSDARG0000002327244


Protein motifs (from Interpro)
Interpro ID Name
 IPR004979  Transcription factor AP-2
 IPR013854  Transcription factor AP-2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0014032 neural crest cell development IGI
 biological_processGO:0014036 neural crest cell fate specification IGI
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043049 otic placode formation IGI
 biological_processGO:0060788 ectodermal placode formation IGI
 biological_processGO:0071696 ectodermal placode development IGI
 biological_processGO:0071698 olfactory placode development IGI
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of cell cycle factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000013 cranial ganglion cranial ganglion absent , abnormal
cranial ganglion perineuronal satellite cell absent , abnormal
Show

 ZFA:0000034 lateral line system lateral line system myelinating Schwann cell absent , abnormal
Show

 ZFA:0000035 lens lens aplastic , abnormal
Show

 ZFA:0000040 median fin fold median fin fold aplastic , abnormal
Show

 ZFA:0000048 olfactory placode olfactory placode aplastic , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle hypoplastic , abnormal
Show

 ZFA:0000106 extension extension aplastic , abnormal
Show

 ZFA:0000122 lens placode lens placode aplastic , abnormal
Show

 ZFA:0000130 olfactory pit olfactory pit aplastic , abnormal
Show

 ZFA:0000138 otic placode otic placode aplastic , abnormal
Show

 ZFA:0000152 retina retina malformed , abnormal
Show

 ZFA:0000162 trigeminal placode trigeminal placode aplastic , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion absent , abnormal
Show

 ZFA:0000559 otolith organ otolith organ decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks all parts of type neural crest cell , abnormal
whole organism curved ventral , abnormal
whole organism morphology , abnormal
whole organism lacks all parts of type melanocyte , abnormal
Show

 ZFA:0001114 head head edematous , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
Show

 ZFA:0001155 enteric nervous system enteric nervous system neuron absent , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin aplastic , abnormal
Show

 ZFA:0001198 adenohypophyseal placode adenohypophyseal placode aplastic , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton aplastic , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage aplastic , abnormal
Show

 ZFA:0001470 anterior lateral line anterior lateral line aplastic , abnormal
Show

 ZFA:0001555 epibranchial ganglion epibranchial ganglion aplastic , abnormal
Show

 ZFA:0001576 sympathetic nervous system sympathetic nervous system neuron absent , abnormal
Show

 ZFA:0007062 olfactory field olfactory field aplastic , abnormal
Show

 ZFA:0009091 melanocyte melanocyte absent , abnormal
melanocyte decreased amount , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron distributed , abnormal
Rohon-Beard neuron decreased amount , abnormal
Show

 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
Show

 ZFA:0009366 hair cell hair cell absent , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000059279 tfap2a / transcription factor AP-2 alpha / P05549*  / reaction / complex
 ENSDARG00000074056 kctd1 / potassium channel tetramerization domain containing 1 / Q5M956* / Q719H9* / BTB/POZ domain-containing protein KCTD1 *  / reaction / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / reaction / complex
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000007241 mycb / Q7ZVS9 / MYC proto-oncogene, bHLH transcription factor b / MYC* / Bmyc* / P01106* / P01108* / Q6P8Z1* / Protein B-Myc * / myelocytomatosis oncogene* / MYC proto-oncogene, bHLH transc...  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000101009 cited4b / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b / Q9WUL8* / CITED4* / Q96RK1* / Cbp/p300-interacting transactivator 4 * / Cbp/p300 interacting t...  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr