ENSDARG00000014329


Danio rerio

Features
Gene ID: ENSDARG00000014329
  
Biological name :npm1a
  
Synonyms : npm1a / nucleophosmin 1a
  
Possible biological names infered from orthology : NPM1 / nucleophosmin 1 / P06748 / Q61937
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 22034477
Gene end: 22045119
  
Corresponding Affymetrix probe sets: Dr.19937.1.S1_at (Zebrafish Array)   Dr.19937.1.S2_at (Zebrafish Array)   NM_199428_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000017747
Ensembl peptide - ENSDARP00000122531
Ensembl peptide - ENSDARP00000117965
Ensembl peptide - ENSDARP00000091299
NCBI entrez gene - 266985     See in Manteia.
RefSeq - NM_199428
RefSeq Peptide - NP_955460
swissprot - A0A0A0MPF3
swissprot - E9QGH7
swissprot - F1QGI4
swissprot - E7FCU0
ZFIN ID - ZDB-GENE-021028-1
Ensembl - ENSDARG00000014329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPM1ENSGALG00000002197Gallus gallus
 NPM1ENSG00000181163Homo sapiens
 Npm1ENSMUSG00000057113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
npm1b / nucleophosmin 1bENSDARG0000003767542
npm2b / nucleophosmin/nucleoplasmin, 2b / NPM2* / Q86SE8* / nucleophosmin/nucleoplasmin 2*ENSDARG0000005396320
npm3 / nucleophosmin/nucleoplasmin, 3 / O75607* / Q9CPP0* / Nucleoplasmin-3 *ENSDARG0000010359420
npm2a / nucleophosmin/nucleoplasmin, 2aENSDARG0000007639114


Protein motifs (from Interpro)
Interpro ID Name
 IPR004301  Nucleoplasmin family
 IPR024057  Nucleoplasmin core domain
 IPR032569  Nucleophosmin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030097 hemopoiesis IMP
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009324 myeloid cell myeloid cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019130 plk2b / polo-like kinase 2b (Drosophila) / PLK2* / Q9NYY3* / P53351* / polo like kinase 2* / Serine/threonine-protein kinase PLK2 *  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000059279 tfap2a / transcription factor AP-2 alpha / P05549*  / reaction / complex
 ENSDARG00000090752 plk2a / polo-like kinase 2a (Drosophila) / PLK2* / Q9NYY3* / polo like kinase 2*  / reaction






 

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