ENSMUSG00000057113


Mus musculus

Features
Gene ID: ENSMUSG00000057113
  
Biological name :Npm1
  
Synonyms : Npm1 / nucleophosmin 1 / Q61937
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 33152287
Gene end: 33163206
  
Corresponding Affymetrix probe sets: 10362593 (MoGene1.0st)   10363178 (MoGene1.0st)   10385043 (MoGene1.0st)   10583340 (MoGene1.0st)   1415839_a_at (Mouse Genome 430 2.0 Array)   1432416_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075067
Ensembl peptide - ENSMUSP00000090891
Ensembl peptide - ENSMUSP00000098926
Ensembl peptide - ENSMUSP00000104978
NCBI entrez gene - 18148     See in Manteia.
MGI - MGI:106184
RefSeq - NM_008722
RefSeq - NM_001252260
RefSeq - NM_001252261
RefSeq Peptide - NP_001239189
RefSeq Peptide - NP_001239190
RefSeq Peptide - NP_032748
swissprot - Q5SQB0
swissprot - Q5SQB5
swissprot - Q5SQB7
swissprot - Q61937
swissprot - Q9DAY9
Ensembl - ENSMUSG00000057113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npm1aENSDARG00000014329Danio rerio
 NPM1ENSGALG00000002197Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npm2 / Q80W85 / Nucleoplasmin-2 / Q86SE8* / nucleophosmin/nucleoplasmin 2*ENSMUSG0000004791124
Npm3 / Q9CPP0 / Nucleoplasmin-3 / O75607* / nucleophosmin/nucleoplasmin 3*ENSMUSG0000005620918


Protein motifs (from Interpro)
Interpro ID Name
 IPR004301  Nucleoplasmin family
 IPR024057  Nucleoplasmin core domain
 IPR032569  Nucleophosmin, C-terminal
 IPR036824  Nucleoplasmin core domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000055 ribosomal large subunit export from nucleus IMP
 biological_processGO:0000056 ribosomal small subunit export from nucleus IDA
 biological_processGO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006334 nucleosome assembly ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006407 rRNA export from nucleus IMP
 biological_processGO:0006884 cell volume homeostasis IMP
 biological_processGO:0006913 nucleocytoplasmic transport ISO
 biological_processGO:0007098 centrosome cycle ISS
 biological_processGO:0007569 cell aging ISS
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0009303 rRNA transcription IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0010825 positive regulation of centrosome duplication IGI
 biological_processGO:0010826 negative regulation of centrosome duplication ISO
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity ISO
 biological_processGO:0034644 cellular response to UV ISO
 biological_processGO:0042273 ribosomal large subunit biogenesis IMP
 biological_processGO:0042274 ribosomal small subunit biogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IGI
 biological_processGO:0043523 regulation of neuron apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046599 regulation of centriole replication ISS
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051054 positive regulation of DNA metabolic process IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0060699 regulation of endoribonuclease activity ISO
 biological_processGO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA ISO
 biological_processGO:0071394 cellular response to testosterone stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1900264 positive regulation of DNA-directed DNA polymerase activity IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition ISO
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IMP
 cellular_componentGO:0001652 granular component IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015934 large ribosomal subunit IDA
 cellular_componentGO:0015935 small ribosomal subunit IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031616 spindle pole centrosome ISO
 cellular_componentGO:0032993 protein-DNA complex ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0004860 protein kinase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019843 rRNA binding IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030957 Tat protein binding ISO
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043023 ribosomal large subunit binding ISO
 molecular_functionGO:0043024 ribosomal small subunit binding ISO
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051059 NF-kappaB binding ISS
 molecular_functionGO:0051082 unfolded protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Npm1tm1Gsva/Npm1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Rps/Pten+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

Allelic Composition: Npm1Gt(OST331547)Lex/Npm1Gt(OST331547)Lex
Genetic Background: B6;129S5-Npm1Gt(OST331547)Lex/Mmucd

Allelic Composition: Npm1tm1Hft/Npm1tm1Hft
Genetic Background: involves: 129

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Npm1tm1Ppp/Npm1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Npm1tm2Ppp/Npm1tm2Ppp
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011877 absent liver "absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage" [MGI:Colin_McKerlie]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+,Npm1tm1Gsva/Npm1+,TgTn(pb-sb-GrOnc)#aGsva/0,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Npm1Gt(VICTR37)704Lex/Npm1Gt(VICTR37)704Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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