ENSGALG00000002197


Gallus gallus

Features
Gene ID: ENSGALG00000002197
  
Biological name :NPM1
  
Synonyms : NPM1 / nucleophosmin
  
Possible biological names infered from orthology : nucleophosmin 1 / P06748 / Q61937
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 3270868
Gene end: 3282126
  
Corresponding Affymetrix probe sets: Gga.12636.1.A1_at (Chicken Array)   Gga.4847.1.S1_x_at (Chicken Array)   Gga.4847.3.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046486
Ensembl peptide - ENSGALP00000058806
Ensembl peptide - ENSGALP00000058740
Ensembl peptide - ENSGALP00000003431
NCBI entrez gene - 396203     See in Manteia.
RefSeq - NM_205267
RefSeq Peptide - NP_990598
swissprot - A0A1L1RJ18
swissprot - A0A1D5P1F0
swissprot - F1NVA4
Ensembl - ENSGALG00000002197
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npm1aENSDARG00000014329Danio rerio
 NPM1ENSG00000181163Homo sapiens
 Npm1ENSMUSG00000057113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPM3 / nucleophosmin/nucleoplasmin 3 / O75607* / Q9CPP0* / Nucleoplasmin-3 *ENSGALG0000003232919


Protein motifs (from Interpro)
Interpro ID Name
 IPR004301  Nucleoplasmin family
 IPR024057  Nucleoplasmin core domain
 IPR032569  Nucleophosmin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000055 ribosomal large subunit export from nucleus IEA
 biological_processGO:0000056 ribosomal small subunit export from nucleus IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006407 rRNA export from nucleus IEA
 biological_processGO:0006884 cell volume homeostasis IEA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008104 protein localization IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0010826 negative regulation of centrosome duplication IEA
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0042274 ribosomal small subunit biogenesis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046599 regulation of centriole replication IEA
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060699 regulation of endoribonuclease activity IEA
 biological_processGO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA IEA
 biological_processGO:1902629 regulation of mRNA stability involved in cellular response to UV IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 biological_processGO:1904751 positive regulation of protein localization to nucleolus IEA
 cellular_componentGO:0001652 granular component IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015934 large ribosomal subunit IEA
 cellular_componentGO:0015935 small ribosomal subunit IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031616 spindle pole centrosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030957 Tat protein binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043023 ribosomal large subunit binding IEA
 molecular_functionGO:0043024 ribosomal small subunit binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr