ENSDARG00000019130


Danio rerio

Features
Gene ID: ENSDARG00000019130
  
Biological name :plk2b
  
Synonyms : plk2b / polo-like kinase 2b (Drosophila)
  
Possible biological names infered from orthology : P53351 / PLK2 / polo like kinase 2 / Q9NYY3 / Serine/threonine-protein kinase PLK2
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 17078692
Gene end: 17086195
  
Corresponding Affymetrix probe sets: Dr.18177.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000025106
NCBI entrez gene - 565576     See in Manteia.
RefSeq - NM_001099245
RefSeq Peptide - NP_001092715
swissprot - A8WHV5
ZFIN ID - ZDB-GENE-070720-17
Ensembl - ENSDARG00000019130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLK2ENSGALG00000014725Gallus gallus
 PLK2ENSG00000145632Homo sapiens
 Plk2ENSMUSG00000021701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plk2a / polo-like kinase 2a (Drosophila) / PLK2* / Q9NYY3* / polo like kinase 2*ENSDARG0000009075271
plk3 / polo-like kinase 3 (Drosophila) / Q9H4B4* / polo like kinase 3* / serine/threonine-protein kinase PLK3 isoform 2 *ENSDARG0000003875449
plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*ENSDARG0000005847135
plk4 / polo-like kinase 4 (Drosophila) / Q64702* / O00444* / polo like kinase 4* / Serine/threonine-protein kinase PLK4 *ENSDARG0000000457622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel hypoplastic , abnormal
intersegmental vessel lamellipodium decreased amount , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic/hypoplastic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018121 cenpj / centromere protein J / Q569L8* / Q9HC77*  / reaction
 ENSDARG00000014329 npm1a / nucleophosmin 1a / NPM1* / Q61937* / P06748* / nucleophosmin 1*  / reaction






 

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