ENSDARG00000058471


Danio rerio

Features
Gene ID: ENSDARG00000058471
  
Biological name :plk1
  
Synonyms : plk1 / polo-like kinase 1 (Drosophila)
  
Possible biological names infered from orthology : P53350 / polo like kinase 1 / Q07832
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 9153141
Gene end: 9161843
  
Corresponding Affymetrix probe sets: Dr.20131.4.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000075786
NCBI entrez gene - 280649     See in Manteia.
RefSeq - NM_001003890
RefSeq Peptide - NP_001003890
swissprot - Q6DRK7
ZFIN ID - ZDB-GENE-021115-7
Ensembl - ENSDARG00000058471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLK1ENSGALG00000006110Gallus gallus
 PLK1ENSG00000166851Homo sapiens
 Plk1ENSMUSG00000030867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plk2b / polo-like kinase 2b (Drosophila) / PLK2* / Q9NYY3* / P53351* / polo like kinase 2* / Serine/threonine-protein kinase PLK2 *ENSDARG0000001913038
plk3 / polo-like kinase 3 (Drosophila) / Q9H4B4* / polo like kinase 3* / serine/threonine-protein kinase PLK3 isoform 2 *ENSDARG0000003875438
plk2a / polo-like kinase 2a (Drosophila) / PLK2* / Q9NYY3* / polo like kinase 2*ENSDARG0000009075236
plk4 / polo-like kinase 4 (Drosophila) / Q64702* / O00444* / polo like kinase 4* / Serine/threonine-protein kinase PLK4 *ENSDARG0000000457624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000959  POLO box domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033695  Second polo-box domain
 IPR033701  First polo-box domain
 IPR033702  Polo-like kinase 1, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain structure , abnormal
brain necrotic , abnormal
brain apoptotic process increased process quality , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000040 median fin fold median fin fold apoptotic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000075 spinal cord spinal cord apoptotic , abnormal
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 ZFA:0000077 tail bud tail bud apoptotic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye apoptotic process increased process quality , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0000217 inner ear inner ear decreased size , abnormal
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 ZFA:0000368 integument integument fragile , abnormal
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 ZFA:0000641 cranial nerve cranial nerve neuron projection absent , abnormal
cranial nerve neuron projection physical object quality , abnormal
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 ZFA:0000737 cranium cranium cartilage element absent , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head deformed , abnormal
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 ZFA:0001115 trunk trunk decreased thickness , abnormal
trunk degenerate , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium absent , abnormal
splanchnocranium hypoplastic , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch apoptotic process increased process quality , abnormal
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 ZFA:0001580 neurocranium neurocranium absent , abnormal
neurocranium malformed , abnormal
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 ZFA:0009000 cell cell centrosome position , abnormal
cell centrosome variability of size , abnormal
cell mitotic spindle disorganized , abnormal
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 ZFA:0009248 neuron neuron decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000063197 golga2 / golgin A2 / A6NMD2* / A7E2F4* / A8MQT2* / A8MZA4* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* / Q08AF8* / Q8N9W4* / Q921M4* ...  / complex
 ENSDARG00000093864 wee1 / WEE1 G2 checkpoint kinase / P30291* / P47810* / WEE 1 homolog 1 (S. pombe)*  / reaction
 ENSDARG00000098897 pds5b / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000074730 pkmyt1 / protein kinase, membrane associated tyrosine/threonine 1 / Q99640* / Q9ESG9* / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase *  / reaction
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / reaction
 ENSDARG00000044491 kif20a / kinesin family member 20A / O95235* / P97329* / Kinesin-like protein KIF20A *  / reaction
 ENSDARG00000037174 nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *  / reaction
 ENSDARG00000013719 gtse1 / G-2 and S-phase expressed 1 / Q8R080* / Q9NYZ3* / G2 and S phase-expressed protein 1 *  / reaction / complex
 ENSDARG00000015254 fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*  / reaction
 ENSDARG00000044144 wapla / WAPL cohesin release factor a / WAPL* / Q7Z5K2* / Q65Z40* / WAPL cohesin release factor*  / reaction
 ENSDARG00000014943 kif23 / kinesin family member 23 / E9Q5G3* / Q02241* / Kinesin-like protein KIF23 *  / reaction
 ENSDARG00000055022 pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSDARG00000029663 rab1ab / RAB1A, member RAS oncogene family b / Rab1* / RAB1A* / P62821* / P62820* / Ras-related protein Rab-1A * / RAB1A, member RAS oncogene family*  / complex
 ENSDARG00000067920 rab8a / RAB8A, member RAS oncogene family / P55258* / P61006*  / reaction
 ENSDARG00000042688 bora / bora, aurora kinase A activator / Q6PGQ7* / Q8BS90* / Protein aurora borealis *  / reaction / complex






 

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