ENSDARG00000037174


Danio rerio

Features
Gene ID: ENSDARG00000037174
  
Biological name :nek12
  
Synonyms : nek12 / NIMA-related kinase 12
  
Possible biological names infered from orthology : NEK9 / NIMA related kinase 9 / Q8K1R7 / Q8TD19 / Serine/threonine-protein kinase Nek9
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 28426602
Gene end: 28432699
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000054061
Ensembl peptide - ENSDARP00000153380
NCBI entrez gene - 548344     See in Manteia.
RefSeq - NM_001017548
RefSeq Peptide - NP_001017548
swissprot - Q56A46
ZFIN ID - ZDB-GENE-050410-11
Ensembl - ENSDARG00000037174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEK9ENSGALG00000010314Gallus gallus
 NEK9ENSG00000119638Homo sapiens
 Nek9ENSMUSG00000034290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nek4 / NIMA-related kinase 4 / P51957*ENSDARG0000004015227
nek8 / NIMA-related kinase 8 / Q86SG6* / Q91ZR4* / Serine/threonine-protein kinase Nek8 *ENSDARG0000004562625
nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *ENSDARG0000000561923
NEK3 / NIMA related kinase 3 / P51956*ENSDARG0000005886922
nek11 / NIMA-related kinase 11 / Q8C0Q4* / Q8NG66* / Serine/threonine-protein kinase Nek11 *ENSDARG0000008756421
nek7 / NIMA-related kinase 7 / Q8TDX7* / Q9ES74* / Serine/threonine-protein kinase Nek7 *ENSDARG0000005696617
nek6 / NIMA-related kinase 6 / Q9ES70* / Q9HC98* / Serine/threonine-protein kinase Nek6 *ENSDARG0000003796317
nek1 / NIMA-related kinase 1 / P51954* / Q96PY6* / NIMA (never in mitosis gene a)-related expressed kinase 1*ENSDARG0000002235015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058471 plk1 / polo-like kinase 1 (Drosophila) / P53350* / Q07832* / polo like kinase 1*  / reaction
 ENSDARG00000037174 nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *  / complex
 ENSDARG00000037963 nek6 / NIMA-related kinase 6 / Q9ES70* / Q9HC98* / Serine/threonine-protein kinase Nek6 *  / reaction / complex
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / reaction






 

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