ENSDARG00000045626


Danio rerio

Features
Gene ID: ENSDARG00000045626
  
Biological name :nek8
  
Synonyms : nek8 / NIMA-related kinase 8
  
Possible biological names infered from orthology : Q86SG6 / Q91ZR4 / Serine/threonine-protein kinase Nek8
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 15479442
Gene end: 15514013
  
Corresponding Affymetrix probe sets: Dr.12587.1.S1_at (Zebrafish Array)   NM_139077_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000067094
NCBI entrez gene - 171094     See in Manteia.
RefSeq - NM_139077
RefSeq Peptide - NP_620776
swissprot - F1R1P5
ZFIN ID - ZDB-GENE-020509-1
Ensembl - ENSDARG00000045626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEK8ENSG00000160602Homo sapiens
 Nek8ENSMUSG00000017405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nek4 / NIMA-related kinase 4 / P51957*ENSDARG0000004015220
nek11 / NIMA-related kinase 11 / Q8C0Q4* / Q8NG66* / Serine/threonine-protein kinase Nek11 *ENSDARG0000008756417
nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *ENSDARG0000003717417
nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *ENSDARG0000000561916
NEK3 / NIMA related kinase 3 / P51956*ENSDARG0000005886916
nek7 / NIMA-related kinase 7 / Q8TDX7* / Q9ES74* / Serine/threonine-protein kinase Nek7 *ENSDARG0000005696613
nek1 / NIMA-related kinase 1 / P51954* / Q96PY6* / NIMA (never in mitosis gene a)-related expressed kinase 1*ENSDARG0000002235013
nek6 / NIMA-related kinase 6 / Q9ES70* / Q9HC98* / Serine/threonine-protein kinase Nek6 *ENSDARG0000003796312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart centered , abnormal
heart position , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cell detached from pronephros pronephric glomerular basement membrane, abnormal
Show

 ZFA:0000151 pronephros pronephros cystic , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved ventral , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus pronephric tubule increased diameter , abnormal
pronephric glomerulus cystic , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule increased diameter , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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