ENSMUSG00000017405


Mus musculus

Features
Gene ID: ENSMUSG00000017405
  
Biological name :Nek8
  
Synonyms : Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8
  
Possible biological names infered from orthology : NIMA related kinase 8 / Q86SG6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78166106
Gene end: 78176675
  
Corresponding Affymetrix probe sets: 10388758 (MoGene1.0st)   1450337_a_at (Mouse Genome 430 2.0 Array)   1458157_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017549
Ensembl peptide - ENSMUSP00000127554
NCBI entrez gene - 140859     See in Manteia.
MGI - MGI:1890646
RefSeq - XM_006532185
RefSeq - NM_080849
RefSeq - XM_006532183
RefSeq - XM_006532184
RefSeq Peptide - NP_543125
swissprot - E9Q258
swissprot - Q91ZR4
Ensembl - ENSMUSG00000017405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek8ENSDARG00000045626Danio rerio
 NEK8ENSG00000160602Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429036
Nek1 / P51954 / NIMA (never in mitosis gene a)-related expressed kinase 1 / Q96PY6* / NIMA related kinase 1*ENSMUSG0000003164423
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773819
Nek4 / NIMA related kinase 4 / P51957*ENSMUSG0000002191819
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503217
Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*ENSMUSG0000002662217
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147817
Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7 / Q8TDX7* / NIMA related kinase 7*ENSMUSG0000002639314
Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6 / Q9HC98* / NIMA related kinase 6*ENSMUSG0000002674914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035330 regulation of hippo signaling IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097543 ciliary inversin compartment IDA
 cellular_componentGO:0097546 ciliary base IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: Nek8jck/Nek8+,Pkd1tm1Bdgz/Pkd1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0010422 heart right ventricle hypoplasia "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
Show

Allelic Composition: Kdrtm1Jrt/Kdr+,Ptentm1Hwu/Ptentm1Hwu,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: B6.129-Twist2tm1.1(cre)Dor Kdrtm1Jrt Ptentm1Hwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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