ENSMUSG00000031644


Mus musculus

Features
Gene ID: ENSMUSG00000031644
  
Biological name :Nek1
  
Synonyms : Nek1 / NIMA (never in mitosis gene a)-related expressed kinase 1 / P51954
  
Possible biological names infered from orthology : NIMA related kinase 1 / Q96PY6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.1
Gene start: 60993195
Gene end: 61131346
  
Corresponding Affymetrix probe sets: 10571922 (MoGene1.0st)   1434267_at (Mouse Genome 430 2.0 Array)   1453612_at (Mouse Genome 430 2.0 Array)   1458211_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147258
Ensembl peptide - ENSMUSP00000147809
Ensembl peptide - ENSMUSP00000034065
Ensembl peptide - ENSMUSP00000113932
NCBI entrez gene - 18004     See in Manteia.
MGI - MGI:97303
RefSeq - XM_017312611
RefSeq - NM_001293637
RefSeq - NM_001293638
RefSeq - NM_001293639
RefSeq - NM_175089
RefSeq - XM_006509294
RefSeq - XM_017312608
RefSeq - XM_017312609
RefSeq - XM_017312610
RefSeq Peptide - NP_001280568
RefSeq Peptide - NP_780298
RefSeq Peptide - NP_001280566
RefSeq Peptide - NP_001280567
swissprot - P51954
swissprot - B2RXX0
swissprot - B7ZWK0
swissprot - B2RXQ4
Ensembl - ENSMUSG00000031644
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek1ENSDARG00000022350Danio rerio
 NEK1ENSGALG00000009683Gallus gallus
 NEK1ENSG00000137601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773820
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147816
Nek4 / NIMA related kinase 4 / P51957*ENSMUSG0000002191816
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429015
Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8 / Q86SG6* / NIMA related kinase 8*ENSMUSG0000001740513
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503212
Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*ENSMUSG0000002662211
Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7 / Q8TDX7* / NIMA related kinase 7*ENSMUSG000000263938
Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6 / Q9HC98* / NIMA related kinase 6*ENSMUSG000000267498


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042769 DNA damage response, detection of DNA damage IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IMP
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tlr6m4Btlr/Tlr6m4Btlr
Genetic Background: C57BL/6J-Tlr6m4Btlr

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000440 domed skull 
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: B6.RBF(C3Fe)-Nek1kat/J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000829 dilated fourth ventricle "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: B6.RBF(C3Fe)-Nek1kat/J

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * RBF/Dn

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: B6.RBF(C3Fe)-Nek1kat/J

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nek1kat/Nek1kat
Genetic Background: B6.RBF(C3Fe)-Nek1kat/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr