ENSMUSG00000026393


Mus musculus

Features
Gene ID: ENSMUSG00000026393
  
Biological name :Nek7
  
Synonyms : Nek7 / Q9ES74 / Serine/threonine-protein kinase Nek7
  
Possible biological names infered from orthology : NIMA related kinase 7 / Q8TDX7
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 138482875
Gene end: 138620141
  
Corresponding Affymetrix probe sets: 10358259 (MoGene1.0st)   1416816_at (Mouse Genome 430 2.0 Array)   1416817_at (Mouse Genome 430 2.0 Array)   1444753_at (Mouse Genome 430 2.0 Array)   1448474_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027642
Ensembl peptide - ENSMUSP00000140635
Ensembl peptide - ENSMUSP00000140903
NCBI entrez gene - 59125     See in Manteia.
MGI - MGI:1890645
RefSeq - NM_001311148
RefSeq - NM_021605
RefSeq Peptide - NP_001298077
RefSeq Peptide - NP_067618
swissprot - Q3TN15
swissprot - Q9ES74
Ensembl - ENSMUSG00000026393
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek7ENSDARG00000056966Danio rerio
 NEK7ENSGALG00000002216Gallus gallus
 NEK7ENSG00000151414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nek6 / Q9ES70 / Serine/threonine-protein kinase Nek6 / Q9HC98* / NIMA related kinase 6*ENSMUSG0000002674978
Nek3 / Q9R0A5 / Serine/threonine-protein kinase Nek3 / P51956* / NIMA related kinase 3*ENSMUSG0000003147834
Nek9 / Q8K1R7 / Serine/threonine-protein kinase Nek9 / Q8TD19* / NIMA related kinase 9*ENSMUSG0000003429033
Nek2 / O35942 / Serine/threonine-protein kinase Nek2 / P51955* / NIMA related kinase 2*ENSMUSG0000002662233
Nek4 / NIMA related kinase 4 / P51957*ENSMUSG0000002191833
Nek8 / Q91ZR4 / Serine/threonine-protein kinase Nek8 / Q86SG6* / NIMA related kinase 8*ENSMUSG0000001740532
Nek1 / P51954 / NIMA (never in mitosis gene a)-related expressed kinase 1 / Q96PY6* / NIMA related kinase 1*ENSMUSG0000003164432
Nek5 / Q7TSC3 / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA. / Q6P3R8* / NIMA related kinase 5*ENSMUSG0000003773830
Nek11 / Q8C0Q4 / Serine/threonine-protein kinase Nek11 / Q8NG66* / NIMA related kinase 11*ENSMUSG0000003503229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:1904355 positive regulation of telomere capping ISO
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nek7M1Btlr/Nek7+
Genetic Background: C57BL/6J-Nek7M1Btlr

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nek7M1Btlr/Nek7+
Genetic Background: C57BL/6J-Nek7M1Btlr

 MP:0003708 binucleate "two nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nek7M1Btlr/Nek7+
Genetic Background: C57BL/6J-Nek7M1Btlr

 MP:0008685 decreased interleukin-18 secretion "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Mir203tm1.1Yir/Mir203tm1.1Yir,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nek7M1Btlr/Nek7+
Genetic Background: C57BL/6J-Nek7M1Btlr

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

Allelic Composition: Nek7tm1b(EUCOMM)Hmgu/Nek7tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nek7tm1b(EUCOMM)Hmgu/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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