ENSG00000151414


Homo sapiens

Features
Gene ID: ENSG00000151414
  
Biological name :NEK7
  
Synonyms : NEK7 / NIMA related kinase 7 / Q8TDX7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q31.3
Gene start: 198156963
Gene end: 198322420
  
Corresponding Affymetrix probe sets: 212530_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375835
Ensembl peptide - ENSP00000444621
Ensembl peptide - ENSP00000439095
Ensembl peptide - ENSP00000392745
Ensembl peptide - ENSP00000356353
Ensembl peptide - ENSP00000356355
NCBI entrez gene - 140609     See in Manteia.
OMIM - 606848
RefSeq - XM_017000344
RefSeq - XM_017000347
RefSeq - XM_017000346
RefSeq - XM_017000345
RefSeq - NM_133494
RefSeq Peptide - NP_598001
swissprot - Q8TDX7
swissprot - C9J1H8
swissprot - F8WAG2
swissprot - F5H3U7
swissprot - A0A024R964
Ensembl - ENSG00000151414
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek7ENSDARG00000056966Danio rerio
 NEK7ENSGALG00000002216Gallus gallus
 Nek7ENSMUSG00000026393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEK6 / Q9HC98 / NIMA related kinase 6ENSG0000011940879
NEK2 / P51955 / NIMA related kinase 2ENSG0000011765033
NEK9 / Q8TD19 / NIMA related kinase 9ENSG0000011963833
NEK1 / Q96PY6 / NIMA related kinase 1ENSG0000013760133
NEK4 / P51957 / NIMA related kinase 4ENSG0000011490433
NEK8 / Q86SG6 / NIMA related kinase 8ENSG0000016060232
NEK3 / P51956 / NIMA related kinase 3ENSG0000013609832
NEK11 / Q8NG66 / NIMA related kinase 11ENSG0000011467030
NEK5 / Q6P3R8 / NIMA related kinase 5ENSG0000019716830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0051225 spindle assembly TAS
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:1904355 positive regulation of telomere capping IMP
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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