ENSG00000114904


Homo sapiens

Features
Gene ID: ENSG00000114904
  
Biological name :NEK4
  
Synonyms : NEK4 / NIMA related kinase 4 / P51957
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.1
Gene start: 52708449
Gene end: 52770949
  
Corresponding Affymetrix probe sets: 1554659_at (Human Genome U133 Plus 2.0 Array)   204634_at (Human Genome U133 Plus 2.0 Array)   232493_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420231
Ensembl peptide - ENSP00000419666
Ensembl peptide - ENSP00000437703
Ensembl peptide - ENSP00000233027
Ensembl peptide - ENSP00000373227
Ensembl peptide - ENSP00000417119
NCBI entrez gene - 6787     See in Manteia.
OMIM - 601959
RefSeq - XM_017007086
RefSeq - NM_001193533
RefSeq - NM_001348413
RefSeq - NM_001348414
RefSeq - NM_003157
RefSeq - XM_006713310
RefSeq - XM_011534039
RefSeq - XM_011534040
RefSeq - XM_017007085
RefSeq Peptide - NP_001335343
RefSeq Peptide - NP_003148
RefSeq Peptide - NP_001180462
RefSeq Peptide - NP_001335342
swissprot - P51957
swissprot - H7C5M0
swissprot - F8WAX1
swissprot - E7EX48
Ensembl - ENSG00000114904
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek4ENSDARG00000040152Danio rerio
 NEK4ENSGALG00000041428Gallus gallus
 Nek4ENSMUSG00000021918Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEK1 / Q96PY6 / NIMA related kinase 1ENSG0000013760124
NEK11 / Q8NG66 / NIMA related kinase 11ENSG0000011467021
NEK9 / Q8TD19 / NIMA related kinase 9ENSG0000011963819
NEK5 / Q6P3R8 / NIMA related kinase 5ENSG0000019716818
NEK8 / Q86SG6 / NIMA related kinase 8ENSG0000016060217
NEK3 / P51956 / NIMA related kinase 3ENSG0000013609817
NEK2 / P51955 / NIMA related kinase 2ENSG0000011765016
NEK6 / Q9HC98 / NIMA related kinase 6ENSG0000011940812
NEK7 / Q8TDX7 / NIMA related kinase 7ENSG0000015141412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:1900062 regulation of replicative cell aging IMP
 biological_processGO:2000772 regulation of cellular senescence IMP
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0035869 ciliary transition zone IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097014 ciliary plasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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